MHCA

Myosin II heavy chain, component of the actin-based molecular motor (conventional myosin); has actin-activated ATPase activity; myosin II consists of two heavy chains and one essential (mlcE) and one regulatory light chain (mlcR), respectively. Myosin is a protein that binds to actin and has ATPase activity that is activated by actin.

Full Name

Myosin II heavy chain

Function

Myosin is a protein that binds to actin and has ATPase activity that is activated by actin.

Biological Process

Actin-myosin filament sliding Source: dictyBase
Aggregation involved in sorocarp development Source: dictyBase
Bleb assembly Source: dictyBase
Cell motility Source: dictyBase
Chemotaxis Source: dictyBase
Contractile actin filament bundle assembly Source: dictyBase
Contractile vacuole organization Source: dictyBase
Cortical actin cytoskeleton organization Source: dictyBase
Culmination involved in sorocarp development Source: dictyBase
Cytoplasmic actin-based contraction involved in forward cell motility Source: dictyBase
Detection of mechanical stimulus Source: dictyBase
Filopodium assembly Source: dictyBase
Hypotonic response Source: dictyBase
Mitotic cytokinesis Source: dictyBase
Myosin filament assembly Source: dictyBase
Negative regulation of actin filament polymerization Source: dictyBase
Protein localization Source: dictyBase
Pseudopodium retraction Source: dictyBase
Regulation of cell shape Source: dictyBase
Response to cAMP Source: dictyBase
Response to differentiation-inducing factor 1 Source: dictyBase
Response to hydrogen peroxide Source: dictyBase
Response to mechanical stimulus Source: dictyBase
Uropod retraction Source: dictyBase

Cellular Location

Cell cortex
Note: Highest concentration in the posterior cell cortex.

PTM

Phosphorylation inhibits thick filament formation and reduces the actin-activated ATPase activity.