MMP7

This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal hemopexin domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes on chromosome 11. This gene exhibits elevated expression levels in multiple human cancers. [provided by RefSeq, Jan 2016]

Matrix Metallopeptidase 7

Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase.

Collagen catabolic process Source: GO_Central
Extracellular matrix disassembly Source: Reactome
Extracellular matrix organization Source: GO_Central
Membrane protein ectodomain proteolysis Source: ARUK-UCL
Membrane protein intracellular domain proteolysis Source: ARUK-UCL
Positive regulation of cell migration Source: ARUK-UCL
Proteolysis Source: CAFA

Extracellular matrix