MMP7

This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal hemopexin domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes on chromosome 11. This gene exhibits elevated expression levels in multiple human cancers. [provided by RefSeq, Jan 2016]
Full Name
Matrix Metallopeptidase 7
Function
Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase.
Biological Process
Collagen catabolic process Source: GO_Central
Extracellular matrix disassembly Source: Reactome
Extracellular matrix organization Source: GO_Central
Membrane protein ectodomain proteolysis Source: ARUK-UCL
Membrane protein intracellular domain proteolysis Source: ARUK-UCL
Positive regulation of cell migration Source: ARUK-UCL
Proteolysis Source: CAFA
Cellular Location
Extracellular matrix
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Anti-MMP7 antibodies

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Target: MMP7
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: A1155
Application*: ELISA, WB
Target: MMP7
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 4A3
Application*: E, WB
Target: MMP7
Host: Mouse
Specificity: Rat
Clone: CBFYM-2411
Application*: WB, IC, P, C, E
Target: MMP7
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYM-2410
Application*: IF, P
Target: MMP7
Host: Mouse
Specificity: Human
Clone: CBFYM-2409
Application*: WB, IC, P, C, E
Target: MMP7
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYM-2408
Application*: E, WB
Target: MMP7
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYM-0692
Application*: IF, IH
Target: MMP7
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYM-0691
Application*: E, IH, WB
Target: MMP7
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYM-0690
Application*: E, P, WB
Target: MMP7
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBFYM-0200
Application*: F
Target: MMP7
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYM-0027
Application*: F
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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