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Mouse Anti-MMP7 Recombinant Antibody (CBFYM-0690) (CBMAB-M0826-FY)

This product is mouse antibody that recognizes MMP7. The antibody CBFYM-0690 can be used for immunoassay techniques such as: ELISA, IHC-P, WB.
See all MMP7 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-0690
Antibody Isotype
IgG1, k
Application
ELISA, IHC-P, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1, k
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.0, 2% BSA
Concentration
2 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Matrix Metallopeptidase 7
Introduction
This gene encodes a member of the peptidase M10 family of matrix metalloproteinases. Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal hemopexin domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes on chromosome 11. This gene exhibits elevated expression levels in multiple human cancers.
Entrez Gene ID
4316
UniProt ID
P09237
Alternative Names
Matrix Metallopeptidase 7; Matrix Metalloproteinase 7 (Matrilysin, Uterine); Matrix Metalloproteinase-7; Uterine Metalloproteinase; Pump-1 Protease; Matrilysin; Matrin; MPSL1
Function
Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase.
Biological Process
Collagen catabolic process Source: GO_Central
Extracellular matrix disassembly Source: Reactome
Extracellular matrix organization Source: GO_Central
Membrane protein ectodomain proteolysis Source: ARUK-UCL
Membrane protein intracellular domain proteolysis Source: ARUK-UCL
Positive regulation of cell migration Source: ARUK-UCL
Proteolysis Source: CAFA
Cellular Location
Extracellular matrix

Kumar, P., Siripini, S., & Sreedhar, A. S. (2022). The matrix metalloproteinase 7 (MMP7) links Hsp90 chaperone with acquired drug resistance and tumor metastasis. Cancer Reports, 5(12), e1261.

Larochelle, J., Yang, C., Liu, L., & Candelario-Jalil, E. (2022). An unexplored role for MMP-7 (Matrix Metalloproteinase-7) in promoting gut permeability after ischemic stroke. Stroke, 53(10), 3238-3242.

Meng, N., Li, Y., Jiang, P., Bu, X., Ding, J., Wang, Y., ... & Xia, L. (2022). A comprehensive pan-cancer analysis of the tumorigenic role of matrix metallopeptidase 7 (MMP7) across human cancers. Frontiers in Oncology, 12, 916907.

Liao, H. Y., Da, C. M., Liao, B., & Zhang, H. H. (2021). Roles of matrix metalloproteinase-7 (MMP-7) in cancer. Clinical biochemistry, 92, 9-18.

Irvine, K. M., Okano, S., Patel, P. J., Horsfall, L. U., Williams, S., Russell, A., & Powell, E. E. (2021). Serum matrix metalloproteinase 7 (MMP7) is a biomarker of fibrosis in patients with non-alcoholic fatty liver disease. Scientific reports, 11(1), 2858.

Liu, Z., Tan, R. J., & Liu, Y. (2020). The many faces of matrix metalloproteinase-7 in kidney diseases. Biomolecules, 10(6), 960.

Yuan, S., Lin, L. S., Gan, R. H., Huang, L., Wu, X. T., Zhao, Y., ... & Lu, Y. G. (2020). Elevated matrix metalloproteinase 7 expression promotes the proliferation, motility and metastasis of tongue squamous cell carcinoma. BMC cancer, 20, 1-12.

Nomden, M., Beljaars, L., Verkade, H. J., Hulscher, J. B., & Olinga, P. (2020). Current concepts of biliary atresia and matrix metalloproteinase-7: a review of literature. Frontiers in medicine, 7, 617261.

Wu, J. F., Jeng, Y. M., Chen, H. L., Ni, Y. H., Hsu, H. Y., & Chang, M. H. (2019). Quantification of serum matrix metallopeptide 7 levels may assist in the diagnosis and predict the outcome for patients with biliary atresia. The Journal of pediatrics, 208, 30-37.

Arvidsson, M., Ahmed, A., Bouzina, H., & Rådegran, G. (2019). Matrix metalloproteinase 7 in diagnosis and differentiation of pulmonary arterial hypertension. Pulmonary Circulation, 9(4), 2045894019895414.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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