Mouse Anti-MMP7 (AA 18-267) Recombinant Antibody (CBFYM-0027) (CBMAB-M0032-FY)

Name: Mouse Anti-MMP7 (AA 18-267) Recombinant Antibody (CBFYM-0027)
SKU: CBMAB-M0032-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYM-0027

Application

Immunogen

Mouse myeloma cell line NS0-derived recombinant human MMP-7, Leu18-Lys267 (Ala230del)

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 18-267

More Infomation

Target

Full Name

Matrix Metallopeptidase 7

Introduction

This gene encodes a member of the peptidase M10 family of matrix metalloproteinases. Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal hemopexin domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes on chromosome 11. This gene exhibits elevated expression levels in multiple human cancers.

Entrez Gene ID

4316

UniProt ID

P09237

Alternative Names

Matrix Metallopeptidase 7; Matrix Metalloproteinase 7 (Matrilysin, Uterine); Matrix Metalloproteinase-7; Uterine Metalloproteinase; Pump-1 Protease; Matrilysin; Matrin; MPSL1

Function

Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase.

Biological Process

Collagen catabolic process Source: GO_Central
Extracellular matrix disassembly Source: Reactome
Extracellular matrix organization Source: GO_Central
Membrane protein ectodomain proteolysis Source: ARUK-UCL
Membrane protein intracellular domain proteolysis Source: ARUK-UCL
Positive regulation of cell migration Source: ARUK-UCL
Proteolysis Source: CAFA

Cellular Location

Extracellular matrix

Kumar, P., Siripini, S., & Sreedhar, A. S. (2022). The matrix metalloproteinase 7 (MMP7) links Hsp90 chaperone with acquired drug resistance and tumor metastasis. Cancer Reports, 5(12), e1261.

Larochelle, J., Yang, C., Liu, L., & Candelario-Jalil, E. (2022). An unexplored role for MMP-7 (Matrix Metalloproteinase-7) in promoting gut permeability after ischemic stroke. Stroke, 53(10), 3238-3242.

Meng, N., Li, Y., Jiang, P., Bu, X., Ding, J., Wang, Y., ... & Xia, L. (2022). A comprehensive pan-cancer analysis of the tumorigenic role of matrix metallopeptidase 7 (MMP7) across human cancers. Frontiers in Oncology, 12, 916907.

Liao, H. Y., Da, C. M., Liao, B., & Zhang, H. H. (2021). Roles of matrix metalloproteinase-7 (MMP-7) in cancer. Clinical biochemistry, 92, 9-18.

Irvine, K. M., Okano, S., Patel, P. J., Horsfall, L. U., Williams, S., Russell, A., & Powell, E. E. (2021). Serum matrix metalloproteinase 7 (MMP7) is a biomarker of fibrosis in patients with non-alcoholic fatty liver disease. Scientific reports, 11(1), 2858.

Liu, Z., Tan, R. J., & Liu, Y. (2020). The many faces of matrix metalloproteinase-7 in kidney diseases. Biomolecules, 10(6), 960.

Yuan, S., Lin, L. S., Gan, R. H., Huang, L., Wu, X. T., Zhao, Y., ... & Lu, Y. G. (2020). Elevated matrix metalloproteinase 7 expression promotes the proliferation, motility and metastasis of tongue squamous cell carcinoma. BMC cancer, 20, 1-12.

Nomden, M., Beljaars, L., Verkade, H. J., Hulscher, J. B., & Olinga, P. (2020). Current concepts of biliary atresia and matrix metalloproteinase-7: a review of literature. Frontiers in medicine, 7, 617261.

Wu, J. F., Jeng, Y. M., Chen, H. L., Ni, Y. H., Hsu, H. Y., & Chang, M. H. (2019). Quantification of serum matrix metallopeptide 7 levels may assist in the diagnosis and predict the outcome for patients with biliary atresia. The Journal of pediatrics, 208, 30-37.

Arvidsson, M., Ahmed, A., Bouzina, H., & Rådegran, G. (2019). Matrix metalloproteinase 7 in diagnosis and differentiation of pulmonary arterial hypertension. Pulmonary Circulation, 9(4), 2045894019895414.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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