NUP62

The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins and is localized to the nuclear pore central plug. This protein associates with the importin alpha/beta complex which is involved in the import of proteins containing nuclear localization signals. Multiple transcript variants of this gene encode a single protein isoform. [provided by RefSeq]

Full Name

nucleoporin 62kDa

Function

Essential component of the nuclear pore complex (PubMed:1915414).
The N-terminal is probably involved in nucleocytoplasmic transport (PubMed:1915414).
The C-terminal is involved in protein-protein interaction probably via coiled-coil formation, promotes its association with centrosomes and may function in anchorage of p62 to the pore complex (PubMed:1915414, PubMed:24107630).
Plays a role in mitotic cell cycle progression by regulating centrosome segregation, centriole maturation and spindle orientation (PubMed:24107630).
It might be involved in protein recruitment to the centrosome after nuclear breakdown (PubMed:24107630).

Biological Process

Cell agingIEA:Ensembl
Cell deathManual Assertion Based On ExperimentIMP:UniProtKB
Cell surface receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Centriole assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Centrosome cycleManual Assertion Based On ExperimentIMP:UniProtKB
Mitotic centrosome separationManual Assertion Based On ExperimentIMP:UniProtKB
Mitotic metaphase plate congressionManual Assertion Based On ExperimentIMP:UniProtKB
mRNA transportIEA:UniProtKB-KW
Negative regulation of apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of epidermal growth factor receptor signaling pathwayIEA:Ensembl
Negative regulation of MAP kinase activityIEA:Ensembl
Negative regulation of programmed cell deathManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of Ras protein signal transductionIEA:Ensembl
Nucleocytoplasmic transport1 PublicationIC:ComplexPortal
Positive regulation of centriole replicationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of epidermal growth factor receptor signaling pathway1 PublicationNAS:UniProtKB
Positive regulation of I-kappaB kinase/NF-kappaB signalingManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of mitotic cytokinetic processManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of mitotic nuclear divisionManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of protein localization to centrosomeManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Protein import into nucleusManual Assertion Based On ExperimentIBA:GO_Central
Regulation of mitotic spindle organizationManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of Ras protein signal transduction1 PublicationNAS:UniProtKB
Regulation of signal transduction1 PublicationNAS:UniProtKB
RNA export from nucleusManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Nucleus, nuclear pore complex
Cytoplasm, cytoskeleton, spindle pole
Nucleus envelope
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Central region of the nuclear pore, within the transporter (PubMed:1915414).
During mitotic cell division, it associates with the poles of the mitotic spindle (PubMed:24107630).

Involvement in disease

Infantile striatonigral degeneration (SNDI):
Neurological disorder characterized by symmetrical degeneration of the caudate nucleus, putamen, and occasionally the globus pallidus, with little involvement of the rest of the brain. The clinical features include developmental regression, choreoathetosis, dystonia, spasticity, dysphagia, failure to thrive, nystagmus, optic atrophy, and mental retardation.

PTM

O-glycosylated. Contains about 10 N-acetylglucosamine side chain sites predicted for the entire protein, among which only one in the C-terminal.
The inner channel of the NPC has a different redox environment from the cytoplasm and allows the formation of interchain disulfide bonds between some nucleoporins, the significant increase of these linkages upon oxidative stress reduces the permeability of the NPC.