ODF2

The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation. Defects in the outer dense fibers lead to abnormal sperm morphology and infertility. This gene encodes one of the major outer dense fiber proteins. Multiple protein isoforms are encoded by transcript variants of this gene; however, not all isoforms and variants have been fully described. [provided by RefSeq]

Full Name

outer dense fiber of sperm tails 2

Function

Seems to be a major component of sperm tail outer dense fibers (ODF). ODFs are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. May have a modulating influence on sperm motility. Functions as a general scaffold protein that is specifically localized at the distal/subdistal appendages of mother centrioles. Component of the centrosome matrix required for the localization of PLK1 and NIN to the centrosomes. Required for the formation and/or maintenance of normal CETN1 assembly.

Biological Process

Centriole-centriole cohesionManual Assertion Based On ExperimentIGI:GO_Central
Cilium organizationManual Assertion Based On ExperimentIGI:ARUK-UCL
Protein localizationManual Assertion Based On ExperimentIMP:GO_Central
Regulation of cilium assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Spermatid developmentIEA:Ensembl

Cellular Location

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Cell projection, cilium
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole
Cytoplasm, cytoskeleton, spindle pole
Cell projection, cilium, flagellum
Localized at the microtubule organizing centers in interphase and spindle poles in mitosis. Localized at the distal/subdistal appendages of mother centrioles.

PTM

Tyrosine phosphorylated. Phosphorylated by TSSK4 on Ser-95.