PLAA

PLAA (Phospholipase A2 Activating Protein) is a protein coding gene. Diseases associated with PLAA include Neurodevelopmental Disorder With Progressive Microcephaly, Spasticity, And Brain Anomalies and Microcephaly. Among its related pathways are Protein processing in endoplasmic reticulum. Gene Ontology annotations related to this gene include binding and phospholipase A2 activator activity.

phospholipase A2 activating protein

Plays a role in protein ubiquitination, sorting and degradation through its association with VCP (PubMed:27753622).
Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling (By similarity).
May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes (PubMed:27753622).
Plays a role in cerebellar Purkinje cell development (By similarity).
Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF-alpha)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis (PubMed:18291623, PubMed:28007986).

Cellular response to lipopolysaccharideManual Assertion Based On ExperimentIMP:UniProtKB
Inflammatory responseIEA:Ensembl
MacroautophagyManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of protein K63-linked ubiquitinationISS:UniProtKB
Nervous system developmentIEA:UniProtKB-KW
Phospholipid metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of dendrite extensionISS:UniProtKB
Positive regulation of neuron migrationISS:UniProtKB
Positive regulation of phospholipase A2 activityManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of synaptic vesicle recyclingISS:UniProtKB
Prostaglandin metabolic processISS:UniProtKB
Proteasome-mediated ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Ubiquitin recyclingManual Assertion Based On ExperimentIBA:GO_Central
Ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathwayISS:UniProtKB

Nucleus
Cytoplasm
Synapse
Recruited to damaged lysosomes decorated with K48-linked ubiquitin chains.

Neurodevelopmental disorder with progressive microcephaly, spasticity, and brain anomalies (NDMSBA):
An autosomal recessive neurodevelopmental disorder characterized by progressive microcephaly, spastic quadriparesis, global developmental delay, profound intellectual disability and severely impaired or absent motor function. More variable features include seizures and optic atrophy.