PON1

The enzyme encoded by this gene is an arylesterase that mainly hydrolyzes paroxon to produce p-nitrophenol. Paroxon is an organophosphorus anticholinesterase compound that is produced in vivo by oxidation of the insecticide parathion. Polymorphisms in this gene are a risk factor in coronary artery disease. The gene is found in a cluster of three related paraoxonase genes at 7q21.3. [provided by RefSeq]
Full Name
paraoxonase 1
Function
Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation.
Biological Process
Aromatic compound catabolic processManual Assertion Based On ExperimentIDA:BHF-UCL
Carboxylic acid catabolic processManual Assertion Based On ExperimentIDA:BHF-UCL
Cholesterol metabolic processIEA:Ensembl
Organophosphate catabolic processManual Assertion Based On ExperimentIDA:BHF-UCL
Phosphatidylcholine metabolic processManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of bindingManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of cholesterol effluxManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of transporter activityManual Assertion Based On ExperimentIDA:BHF-UCL
Response to fatty acidIEA:Ensembl
Response to fluorideIEA:Ensembl
Response to nutrient levelsIEA:Ensembl
Response to toxic substanceManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Secreted, extracellular space
Involvement in disease
Microvascular complications of diabetes 5 (MVCD5):
Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.
PTM
Glycosylated.
The signal sequence is not cleaved.
Present in two forms, form B contains a disulfide bond, form A does not.
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Anti-PON1 antibodies

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Mouse Anti-PON1 Recombinant Antibody (CBT4465) (V2LY-0625-LY36)

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Target: PON1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4465
Application*: WB, IH, F
Datasheet SDS

Mouse Anti-PON1 Recombinant Antibody (CBT2750) (V2LY-0625-LY35)

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Target: PON1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2750
Application*: WB, IH, IC, F
Datasheet SDS

Mouse Anti-PON1 Recombinant Antibody (4G11) (CBMAB-A6891-LY)

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Target: PON1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 4G11
Application*: WB, E
Datasheet SDS

Mouse Anti-PON1 Recombinant Antibody (2H7) (CBMAB-A6888-LY)

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Target: PON1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2H7
Application*: WB, E
Datasheet SDS

Mouse Anti-PON1 Recombinant Antibody (4G8D3) (CBMAB-P2402-YC)

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Target: PON1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 4G8D3
Application*: WB, IF, P, F, E
Datasheet SDS

Mouse Anti-PON1 Recombinant Antibody (2D4) (CBMAB-P2401-YC)

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Target: PON1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 2D4
Application*: WB, IH, IF, F
Datasheet SDS

Mouse Anti-PON1 Recombinant Antibody (1F7) (CBMAB-P2400-YC)

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Target: PON1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1F7
Application*: WB, IH, F
Datasheet SDS

Mouse Anti-PON1 Recombinant Antibody (CBFYE-1602) (CBMAB-E2259-FY)

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Target: PON1
Host: Mouse
Specificity: Human
Clone: CBFYE-1602
Application*: WB, IC, P, C, E
Datasheet SDS

Rabbit Anti-PON1 Recombinant Antibody (BA0218) (CBMAB-0679CQ)

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Target: PON1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: BA0218
Application*: P, IP, WB
Datasheet SDS

Rabbit Anti-PON1 Recombinant Antibody (BA0219) (CBMAB-0678CQ)

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Target: PON1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: BA0219
Application*: IP, WB
Datasheet SDS

Mouse Anti-PON1 Recombinant Antibody (17A12) (CBMAB-0677CQ)

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Target: PON1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat, Hamster, Monkey
Clone: 17A12
Application*: E, F, IF, IH, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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