PPIB
The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta.
Full Name
peptidylprolyl isomerase B
Alternative Names
Cyclophilin B, CYP S1, CYPB, PPIase B, Rotamase B, S cyclophilin, SCYLP
Function
PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding.
Biological Process
Bone developmentManual Assertion Based On ExperimentIMP:UniProtKB
Chaperone-mediated protein foldingManual Assertion Based On ExperimentIDA:UniProtKB
Neutrophil chemotaxisManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation by host of viral genome replicationManual Assertion Based On ExperimentIMP:AgBase
Positive regulation by host of viral processManual Assertion Based On ExperimentIMP:AgBase
Positive regulation of multicellular organism growthManual Assertion Based On ExperimentIMP:UniProtKB
Protein foldingManual Assertion Based On ExperimentIBA:GO_Central
Protein peptidyl-prolyl isomerizationManual Assertion Based On ExperimentIDA:UniProtKB
Protein stabilizationManual Assertion Based On ExperimentIMP:UniProtKB
Chaperone-mediated protein foldingManual Assertion Based On ExperimentIDA:UniProtKB
Neutrophil chemotaxisManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation by host of viral genome replicationManual Assertion Based On ExperimentIMP:AgBase
Positive regulation by host of viral processManual Assertion Based On ExperimentIMP:AgBase
Positive regulation of multicellular organism growthManual Assertion Based On ExperimentIMP:UniProtKB
Protein foldingManual Assertion Based On ExperimentIBA:GO_Central
Protein peptidyl-prolyl isomerizationManual Assertion Based On ExperimentIDA:UniProtKB
Protein stabilizationManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Virion
(Microbial infection).
Endoplasmic reticulum lumen
Melanosome
Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065).
(Microbial infection).
Endoplasmic reticulum lumen
Melanosome
Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065).
Involvement in disease
Osteogenesis imperfecta 9 (OI9):
A form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI9 is a severe autosomal recessive form of the disorder.
A form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI9 is a severe autosomal recessive form of the disorder.
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Anti-PPIB antibodies
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CompareTarget: PPIB
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EC219
Application*: WB, P, IF
Target: PPIB
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EC218
Application*: WB, P
Target: PPIB
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat
Clone: CF348
Application*: ELISA, WB, IHC
Target: PPIB
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CB333
Application*: WB, IHC
Target: PPIB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 11C11
Application*: FC, IF, IHC-P, ICC, WB
Target: PPIB
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBAb194
Application*: WB
Target: PPIB
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: D1V5J
Application*: WB
Target: PPIB
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat, Mouse
Application*: IF, WB, P
Target: PPIB
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3G118
Application*: E, WB
Target: PPIB
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat, Mouse
Clone: CBXC-0686
Application*: WB
Target: PPIB
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYC-P545
Application*: WB, IC, P, C, E
Target: PPIB
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBYC-P544
Application*: WB, IC, P, C, E
Target: PPIB
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: CBYC-P543
Application*: WB
Target: PPIB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: k2E2
Application*: E, WB
Target: PPIB
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 9H108
Application*: IC, WB
Target: PPIB
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-C2734
Application*: E, P, WB
Target: PPIB
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBFYC-3046
Application*: WB, P
Target: PPIB
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 4E11G1
Application*: E, P, WB
Target: PPIB
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: 2B10
Application*: WB
Target: PPIB
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: 1B3
Application*: WB, P
Target: PPIB
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat
Clone: 549205
Application*: WB, IC
Target: PPIB
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat, Mouse
Clone: CBT27
Application*: IF, IC, WB, P
Target: PPIB
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat, Mouse
Clone: CBT399
Application*: WB, P, IF
Target: PPIB
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat
Clone: CBYY-C0323
Application*: WB, IC
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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