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PPIB

The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta.

Full Name

peptidylprolyl isomerase B

Function

PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding.

Biological Process

Bone developmentManual Assertion Based On ExperimentIMP:UniProtKB
Chaperone-mediated protein foldingManual Assertion Based On ExperimentIDA:UniProtKB
Neutrophil chemotaxisManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation by host of viral genome replicationManual Assertion Based On ExperimentIMP:AgBase
Positive regulation by host of viral processManual Assertion Based On ExperimentIMP:AgBase
Positive regulation of multicellular organism growthManual Assertion Based On ExperimentIMP:UniProtKB
Protein foldingManual Assertion Based On ExperimentIBA:GO_Central
Protein peptidyl-prolyl isomerizationManual Assertion Based On ExperimentIDA:UniProtKB
Protein stabilizationManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Virion
(Microbial infection).
Endoplasmic reticulum lumen
Melanosome
Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065).

Involvement in disease

Osteogenesis imperfecta 9 (OI9):
A form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI9 is a severe autosomal recessive form of the disorder.

Anti-PPIB antibodies

Mouse Anti-PPIB Recombinant Antibody (CBXC-0686) (CBMAB-C3385-CQ)

SDS

Target: PPIB

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Rat, Mouse

Clone: CBXC-0686

Application*: WB

Mouse Anti-PPIB Recombinant Antibody (CBFYC-3046) (CBMAB-C3123-FY)

SDS

Target: PPIB

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CBFYC-3046

Application*: WB, P

Mouse Anti-PPIB Recombinant Antibody (4E11G1) (CBMAB-C6842-LY)

SDS

Target: PPIB

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 4E11G1

Application*: E, P, WB

Mouse Anti-PPIB Recombinant Antibody (2B10) (CBMAB-C4652-LY)

SDS

Target: PPIB

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: 2B10

Application*: WB

Mouse Anti-PPIB Recombinant Antibody (1B3) (CBMAB-C3642-LY)

SDS

Target: PPIB

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: 1B3

Application*: WB, P

Mouse Anti-PPIB Recombinant Antibody (549205) (CBMAB-C3446-LY)

SDS

Target: PPIB

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Mouse, Rat

Clone: 549205

Application*: WB, IC

Mouse Anti-PPIB Recombinant Antibody (CF348) (CBMAB-FT349LY)

SDS

Target: PPIB

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Mouse, Rat

Clone: CF348

Application*: ELISA, WB, IHC

Mouse Anti-PPIB Recombinant Antibody (CB333) (CBMAB-CS333LY)

SDS

Target: PPIB

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CB333

Application*: WB, IHC

Mouse Anti-PPIB Recombinant Antibody (11C11) (CBMAB-BR396LY)

SDS

Target: PPIB

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: 11C11

Application*: FC, IF, IHC-P, ICC, WB

Recombinant Rabbit Anti-PPIB Antibody (CBAb194) (CBMAB-Ab194-LY)

SDS

Target: PPIB

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CBAb194

Application*: WB

Rabbit Anti-PPIB Recombinant Antibody (D1V5J) (CBMAB-CP2056-LY)

SDS

Target: PPIB

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat, Monkey

Clone: D1V5J

Application*: WB

Mouse Anti-PPIB Recombinant Antibody (3G118) (CBMAB-C4149-CN)

SDS

Target: PPIB

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 3G118

Application*: E, WB

Mouse Anti-PPIB Recombinant Antibody (CBYC-P545) (CBMAB-P2518-YC)

SDS

Target: PPIB

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYC-P545

Application*: WB, IC, P, C, E

Mouse Anti-PPIB Recombinant Antibody (CBYC-P544) (CBMAB-P2517-YC)

SDS

Target: PPIB

Host: Mouse

Antibody Isotype: IgG

Specificity: Rat

Clone: CBYC-P544

Application*: WB, IC, P, C, E

Rabbit Anti-PPIB Recombinant Antibody (CBYC-P543) (CBMAB-P2516-YC)

SDS

Target: PPIB

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat, Monkey

Clone: CBYC-P543

Application*: WB

Mouse Anti-PPIB Recombinant Antibody (k2E2) (CBMAB-P2515-YC)

SDS

Target: PPIB

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: k2E2

Application*: E, WB

Mouse Anti-PPIB Recombinant Antibody (9H108) (CBMAB-P2514-YC)

SDS

Target: PPIB

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 9H108

Application*: IC, WB

Mouse Anti-PPIB Recombinant Antibody (CBYY-C2734) (CBMAB-C4175-YY)

SDS

Target: PPIB

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBYY-C2734

Application*: E, P, WB

Mouse Anti-PPIB Recombinant Antibody (CBYY-C0323) (CBMAB-C1087-YY)

SDS

Target: PPIB

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Mouse, Rat

Clone: CBYY-C0323

Application*: WB, IC

Mouse Anti-PPIB Recombinant Antibody (CBMAB-Z0481-LY)

SDS

Target: PPIB

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Rat, Mouse

Application*: IF, WB, P

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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