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RCVRN

This gene encodes a member of the recoverin family of neuronal calcium sensors. The encoded protein contains three calcium-binding EF-hand domains and may prolong the termination of the phototransduction cascade in the retina by blocking the phosphorylation of photo-activated rhodopsin. Recoverin may be the antigen responsible for cancer-associated retinopathy. [provided by RefSeq, Jul 2008]

Full Name

Recoverin

Function

Acts as a calcium sensor and regulates phototransduction of cone and rod photoreceptor cells (By similarity).
Modulates light sensitivity of cone photoreceptor in dark and dim conditions (By similarity).
In response to high Ca2+ levels induced by low light levels, prolongs RHO/rhodopsin activation in rod photoreceptor cells by binding to and inhibiting GRK1-mediated phosphorylation of RHO/rhodopsin (By similarity).
Plays a role in scotopic vision/enhances vision in dim light by enhancing signal transfer between rod photoreceptors and rod bipolar cells (By similarity).
Improves rod photoreceptor sensitivity in dim light and mediates response of rod photoreceptors to facilitate detection of change and motion in bright light (By similarity).

Biological Process

Biological Process phototransductionIEA:Ensembl
Biological Process regulation of calcium ion transportIEA:Ensembl
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process visual perceptionManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Photoreceptor inner segment
Cell projection, cilium, photoreceptor outer segment
Photoreceptor outer segment membrane
Perikaryon
Primarily expressed in the inner segments of light-adapted rod photoreceptors, approximately 10% of which translocates from photoreceptor outer segments upon light stimulation (By similarity).
Targeting of myristoylated protein to rod photoreceptor outer segments is calcium dependent (By similarity).

PTM

The N-terminal glycine is linked to one of four different types of acyl groups. The most abundant is myristoleate (14:1), but 14:0, 14:2, and 12:0 acyl residues are also present (By similarity).
The Ca2+ induced exposure of the myristoyl group, known as the calcium-myristoyl switch, promotes RCVRN binding to the photoreceptor cell membranes only when intracellular Ca2+ concentration is high (By similarity).
Oxidation on Cys-39 occurs in response to prolonged intense illumination and results in the formation of disulfide homodimers, and to a lesser extent disulfide-linked heterodimers.

Anti-RCVRN antibodies

Mouse Anti-RCVRN Recombinant Antibody (4C10) (CBMAB-A7497-LY)

SDS

Target: RCVRN

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 4C10

Application*: WB, E

Mouse Anti-RCVRN Recombinant Antibody (4A8) (CBMAB-A7496-LY)

SDS

Target: RCVRN

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 4A8

Application*: WB, E

Mouse Anti-RCVRN Recombinant Antibody (3H1) (CBMAB-A7495-LY)

SDS

Target: RCVRN

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 3H1

Application*: WB, E

Mouse Anti-RCVRN Recombinant Antibody (3F6) (CBMAB-A7494-LY)

SDS

Target: RCVRN

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 3F6

Application*: WB, E

Mouse Anti-RCVRN Recombinant Antibody (2H4) (CBMAB-A7493-LY)

SDS

Target: RCVRN

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 2H4

Application*: WB, E

Mouse Anti-RCVRN Recombinant Antibody (2B3) (CBMAB-A7492-LY)

SDS

Target: RCVRN

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 2B3

Application*: WB, E

Mouse Anti-RCVRN Recombinant Antibody (2B2) (CBMAB-A7491-LY)

SDS

Target: RCVRN

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 2B2

Application*: WB, E

Mouse Anti-RCVRN Recombinant Antibody (1D3) (CBMAB-A7490-LY)

SDS

Target: RCVRN

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 1D3

Application*: WB, E

Mouse Anti-RCVRN Recombinant Antibody (1B9) (CBMAB-A7489-LY)

SDS

Target: RCVRN

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 1B9

Application*: WB, E

Mouse Anti-RCVRN Recombinant Antibody (1B7) (CBMAB-A7488-LY)

SDS

Target: RCVRN

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 1B7

Application*: WB, E

Mouse Anti-RCVRN Recombinant Antibody (CBCNR-360) (CBMAB-R1972-CN)

SDS

Target: RCVRN

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBCNR-360

Application*: IP, E, WB

Mouse Anti-RCVRN Recombinant Antibody (CBCNR-359) (CBMAB-R1971-CN)

SDS

Target: RCVRN

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBCNR-359

Application*: E, WB

Mouse Anti-RCVRN Recombinant Antibody (CBCNR-358) (CBMAB-R1970-CN)

SDS

Target: RCVRN

Host: Mouse

Specificity: Human

Clone: CBCNR-358

Application*: IF, WB

Mouse Anti-RCVRN Recombinant Antibody (9C50) (CBMAB-R1969-CN)

SDS

Target: RCVRN

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: 9C50

Application*: IF, WB

Mouse Anti-RCVRN Recombinant Antibody (4C6) (CBMAB-R1963-CN)

SDS

Target: RCVRN

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 4C6

Application*: E, WB

Mouse Anti-RCVRN Recombinant Antibody (6A55CD6) (CBMAB-1756-CN)

SDS

Target: RCVRN

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Mouse

Clone: 6A55CD6

Application*: E, IF, WB

RCVRN Matched Antibody Pair (979) (APMAB-979LY)

SDS

Target: RCVRN

Specificity: Human

RCVRN Matched Antibody Pair (978) (APMAB-978LY)

SDS

Target: RCVRN

Specificity: Human

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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