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Mouse Anti-RCVRN Recombinant Antibody (CBCNR-358) (CBMAB-R1970-CN)

This product is a Mouse antibody that recognizes RCVRN. The antibody CBCNR-358 can be used for immunoassay techniques such as: IF, WB.
See all RCVRN antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBCNR-358
Application
IF, WB

Basic Information

Immunogen
Human recombinant recoverin
Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
Tris-Glycine, 0.15M NaCl
Preservative
0.05% Sodium azide
Concentration
4.5 mg/mL

Target

Full Name
Recoverin
Introduction
This gene encodes a member of the recoverin family of neuronal calcium sensors. The encoded protein contains three calcium-binding EF-hand domains and may prolong the termination of the phototransduction cascade in the retina by blocking the phosphorylation of photo-activated rhodopsin. Recoverin may be the antigen responsible for cancer-associated retinopathy. [provided by RefSeq, Jul 2008]
Entrez Gene ID
5957
UniProt ID
P35243
Alternative Names
Recoverin; Cancer-Associated Retinopathy Protein; RCV1; Cancer Associated Retinopathy Antigen; Protein CAR;
Function
Acts as a calcium sensor and regulates phototransduction of cone and rod photoreceptor cells (By similarity).
Modulates light sensitivity of cone photoreceptor in dark and dim conditions (By similarity).
In response to high Ca2+ levels induced by low light levels, prolongs RHO/rhodopsin activation in rod photoreceptor cells by binding to and inhibiting GRK1-mediated phosphorylation of RHO/rhodopsin (By similarity).
Plays a role in scotopic vision/enhances vision in dim light by enhancing signal transfer between rod photoreceptors and rod bipolar cells (By similarity).
Improves rod photoreceptor sensitivity in dim light and mediates response of rod photoreceptors to facilitate detection of change and motion in bright light (By similarity).
Biological Process
Biological Process phototransductionIEA:Ensembl
Biological Process regulation of calcium ion transportIEA:Ensembl
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process visual perceptionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Photoreceptor inner segment
Cell projection, cilium, photoreceptor outer segment
Photoreceptor outer segment membrane
Perikaryon
Primarily expressed in the inner segments of light-adapted rod photoreceptors, approximately 10% of which translocates from photoreceptor outer segments upon light stimulation (By similarity).
Targeting of myristoylated protein to rod photoreceptor outer segments is calcium dependent (By similarity).
PTM
The N-terminal glycine is linked to one of four different types of acyl groups. The most abundant is myristoleate (14:1), but 14:0, 14:2, and 12:0 acyl residues are also present (By similarity).
The Ca2+ induced exposure of the myristoyl group, known as the calcium-myristoyl switch, promotes RCVRN binding to the photoreceptor cell membranes only when intracellular Ca2+ concentration is high (By similarity).
Oxidation on Cys-39 oCcurs in response to prolonged intense illumination and results in the formation of disulfide homodimers, and to a lesser extent disulfide-linked heterodimers.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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