RGMA

This gene encodes a member of the repulsive guidance molecule family. The encoded protein is a glycosylphosphatidylinositol-anchored glycoprotein that functions as an axon guidance protein in the developing and adult central nervous system. This protein may also function as a tumor suppressor in some cancers. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

RGM domain family, member A

Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.

Biological Process BMP signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process membrane protein ectodomain proteolysisIEA:Ensembl
Biological Process negative regulation of axon regenerationIEA:InterPro
Biological Process negative regulation of receptor bindingIEA:Ensembl
Biological Process neural tube closureIEA:Ensembl
Biological Process neuron projection developmentIEA:Ensembl
Biological Process positive regulation of GTPase activityIEA:Ensembl
Biological Process positive regulation of membrane protein ectodomain proteolysisIEA:Ensembl
Biological Process positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process regulation of BMP signaling pathwayIEA:Ensembl

Cell membrane

Autocatalytically cleaved at low pH; the two chains remain linked via two disulfide bonds.