Mouse Anti-RGMA Recombinant Antibody (292012) (CBMAB-R2417-CN)

Name: Mouse Anti-RGMA Recombinant Antibody (292012)
SKU: CBMAB-R2417-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

292012

Application

Immunogen

Mouse myeloma cell line NS0-derived recombinant chicken RGM-A, Pro150-Asn404 (Asn404Asp), predicted, Accession # Q8JG54

Specificity

Chicken

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

LYOPH

Buffer

PBS, Trehalose

Concentration

LYOPH

More Infomation

Target

Full Name

RGM domain family, member A

Introduction

This gene encodes a member of the repulsive guidance molecule family. The encoded protein is a glycosylphosphatidylinositol-anchored glycoprotein that functions as an axon guidance protein in the developing and adult central nervous system. This protein may also function as a tumor suppressor in some cancers. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Entrez Gene ID

395214

UniProt ID

Q8JG54

Alternative Names

Repulsive Guidance Molecule Family Member A; RGM Domain Family, Member A; RGM; Repulsive Guidance Molecule A; RGM Domain Family Member A;

Function

Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.

Biological Process

Biological Process BMP signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process membrane protein ectodomain proteolysisIEA:Ensembl
Biological Process negative regulation of axon regenerationIEA:InterPro
Biological Process negative regulation of receptor bindingIEA:Ensembl
Biological Process neural tube closureIEA:Ensembl
Biological Process neuron projection developmentIEA:Ensembl
Biological Process positive regulation of GTPase activityIEA:Ensembl
Biological Process positive regulation of membrane protein ectodomain proteolysisIEA:Ensembl
Biological Process positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process regulation of BMP signaling pathwayIEA:Ensembl

Cellular Location

Cell membrane

PTM

Autocatalytically cleaved at low pH; the two chains remain linked via two disulfide bonds.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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