Rabbit Anti-RGMA Recombinant Antibody (EP7990(2)) (CBMAB-1763-CN)

Name: Rabbit Anti-RGMA Recombinant Antibody (EP7990(2))
SKU: CBMAB-1763-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

EP7990(2)

Application

IF, WB

Immunogen

Synthetic peptide within Human Repulsive Guidance Molecule A aa. 400 to the C-terminus.

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

50% Glycerol, 0.05% BSA

Preservative

0.01% Sodium azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

RGM domain family, member A

Introduction

This gene encodes a member of the repulsive guidance molecule family. The encoded protein is a glycosylphosphatidylinositol-anchored glycoprotein that functions as an axon guidance protein in the developing and adult central nervous system. This protein may also function as a tumor suppressor in some cancers. Alternate splicing results in multiple transcript variants. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.

Entrez Gene ID

Human	56963
Mouse	244058
Rat	308739

UniProt ID

Human	Q96B86
Mouse	Q6PCX7
Rat	D4A188

Alternative Names

RGM

Function

Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.

Biological Process

Biological Process BMP signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process membrane protein ectodomain proteolysisIEA:Ensembl
Biological Process negative regulation of axon regenerationIEA:InterPro
Biological Process negative regulation of receptor bindingIEA:Ensembl
Biological Process neural tube closureIEA:Ensembl
Biological Process neuron projection developmentIEA:Ensembl
Biological Process positive regulation of GTPase activityIEA:Ensembl
Biological Process positive regulation of membrane protein ectodomain proteolysisIEA:Ensembl
Biological Process positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process regulation of BMP signaling pathwayIEA:Ensembl

Cellular Location

Cell membrane

PTM

Autocatalytically cleaved at low pH; the two chains remain linked via two disulfide bonds.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Rat Anti-RGMA Recombinant Antibody (275407) (CAT#: CBMAB-R2416-CN)

Mouse Anti-RGMA Recombinant Antibody (292012) (CAT#: CBMAB-R2417-CN)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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