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Rabbit Anti-RGMA Recombinant Antibody (EP7990(2)) (CBMAB-1763-CN)

This product is a rabbit antibody that recognizes RGMA of human. The antibody EP7990(2) can be used for immunoassay techniques such as: IF, WB.
See all RGMA antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EP7990(2)
Antibody Isotype
IgG
Application
IF, WB

Basic Information

Immunogen
Synthetic peptide within Human Repulsive Guidance Molecule A aa. 400 to the C-terminus.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% Glycerol, 0.05% BSA
Preservative
0.01% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
RGM domain family, member A
Introduction
This gene encodes a member of the repulsive guidance molecule family. The encoded protein is a glycosylphosphatidylinositol-anchored glycoprotein that functions as an axon guidance protein in the developing and adult central nervous system. This protein may also function as a tumor suppressor in some cancers. Alternate splicing results in multiple transcript variants. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.
Entrez Gene ID
Human56963
Mouse244058
Rat308739
UniProt ID
HumanQ96B86
MouseQ6PCX7
RatD4A188
Alternative Names
RGM
Function
Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.
Biological Process
Biological Process BMP signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process membrane protein ectodomain proteolysisIEA:Ensembl
Biological Process negative regulation of axon regenerationIEA:InterPro
Biological Process negative regulation of receptor bindingIEA:Ensembl
Biological Process neural tube closureIEA:Ensembl
Biological Process neuron projection developmentIEA:Ensembl
Biological Process positive regulation of GTPase activityIEA:Ensembl
Biological Process positive regulation of membrane protein ectodomain proteolysisIEA:Ensembl
Biological Process positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process regulation of BMP signaling pathwayIEA:Ensembl
Cellular Location
Cell membrane
PTM
Autocatalytically cleaved at low pH; the two chains remain linked via two disulfide bonds.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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