SLC8A1

In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also enters the cell through the sarcolemma (plasma membrane). During relaxation, Ca(2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca(2+) that entered across the sarcolemma must be extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary mechanism by which the Ca(2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.[supplied by OMIM, Apr 2004]

Solute Carrier Family 8 Member A1

Mediates the exchange of one Ca2+ ion against three to four Na+ ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca2+ levels and Ca2+-dependent cellular processes (PubMed:1374913, PubMed:11241183, PubMed:1476165).
Contributes to Ca2+ transport during excitation-contraction coupling in muscle (PubMed:1374913, PubMed:11241183, PubMed:1476165).
In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca2+ levels due to release of Ca2+ stores from the endoplasmic reticulum (PubMed:1374913, PubMed:11241183, PubMed:1476165).
SLC8A1 mediates the export of Ca2+ from the cell during the next phase, so that cytoplasmic Ca2+ levels rapidly return to baseline (PubMed:1374913, PubMed:11241183, PubMed:1476165).
Required for normal embryonic heart development and the onset of heart contractions (By similarity).

Biological Process calcium ion exportIDA:BHF-UCL
Biological Process calcium ion homeostasisISS:BHF-UCL
Biological Process calcium ion importManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process calcium ion import across plasma membraneManual Assertion Based On ExperimentIBA:GO_Central
Biological Process calcium ion transmembrane import into cytosolManual Assertion Based On ExperimentTAS:BHF-UCL
Biological Process calcium ion transmembrane transportManual Assertion Based On ExperimentIGI:UniProtKB
Biological Process calcium ion transport into cytosolISS:BHF-UCL
Biological Process cardiac muscle cell developmentISS:BHF-UCL
Biological Process cardiac muscle contractionManual Assertion Based On ExperimentTAS:BHF-UCL
Biological Process cell communication by electrical coupling involved in cardiac conductionISS:BHF-UCL
Biological Process cellular calcium ion homeostasisISS:ARUK-UCL
Biological Process cellular response to caffeineISS:BHF-UCL
Biological Process cellular response to cAMPIEA:Ensembl
Biological Process cellular response to hypoxiaIEA:Ensembl
Biological Process cellular response to reactive oxygen speciesIDA:BHF-UCL
Biological Process cellular sodium ion homeostasisManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process ion transportTAS:Reactome
Biological Process membrane depolarization during cardiac muscle cell action potentialManual Assertion Based On ExperimentTAS:BHF-UCL
Biological Process metal ion transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process muscle contractionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process negative regulation of cytosolic calcium ion concentrationISS:BHF-UCL
Biological Process negative regulation of protein serine/threonine kinase activityISS:ARUK-UCL
Biological Process positive regulation of bone mineralizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of fibroblast migrationIEA:Ensembl
Biological Process positive regulation of the force of heart contractionManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process regulation of cardiac conductionTAS:Reactome
Biological Process regulation of cardiac muscle contraction by calcium ion signalingManual Assertion Based On ExperimentTAS:BHF-UCL
Biological Process regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ionISS:BHF-UCL
Biological Process regulation of cell communication by electrical couplingManual Assertion Based On ExperimentTAS:BHF-UCL
Biological Process regulation of gene expressionISS:ARUK-UCL
Biological Process regulation of heart rateISS:BHF-UCL
Biological Process regulation of sodium ion transportIEA:Ensembl
Biological Process regulation of the force of heart contractionISS:BHF-UCL
Biological Process relaxation of cardiac muscleManual Assertion Based On ExperimentTAS:BHF-UCL
Biological Process relaxation of smooth muscleISS:BHF-UCL
Biological Process response to ATPIEA:Ensembl
Biological Process response to glucoseIEA:Ensembl
Biological Process response to hydrogen peroxideIEA:Ensembl
Biological Process response to immobilization stressIEA:Ensembl
Biological Process response to muscle stretchManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process response to nutrientIEA:Ensembl
Biological Process response to xenobiotic stimulusIEA:Ensembl
Biological Process sodium ion export across plasma membraneIDA:BHF-UCL
Biological Process sodium ion import across plasma membraneManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process sodium ion transmembrane transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process telencephalon developmentIEA:Ensembl
Biological Process vascular associated smooth muscle contractionISS:BHF-UCL

Cell membrane