SRC2

Full Name

SRC2

Function

Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed:8670870, PubMed:23508108, PubMed:9430642).
Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) (PubMed:8670870, PubMed:23508108, PubMed:9430642).
Required with NCOA1 to control energy balance between white and brown adipose tissues (PubMed:8670870, PubMed:23508108, PubMed:9430642).
Critical regulator of glucose metabolism regulation, acts as RORA coactivator to specifically modulate G6PC1 expression (PubMed:8670870, PubMed:23508108, PubMed:9430642).
Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3 (PubMed:23508108).
Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-ARNTL/BMAL1 heterodimer (By similarity).

Biological Process

Biological Process cellular response to hormone stimulusManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cellular response to Thyroglobulin triiodothyronineIEA:Ensembl
Biological Process circadian regulation of gene expressionISS:UniProtKB
Biological Process locomotor rhythmIEA:Ensembl
Biological Process mRNA transcription by RNA polymerase II1 PublicationIC:ComplexPortal
Biological Process negative regulation of transcription by RNA polymerase IIIEA:Ensembl
Biological Process peroxisome proliferator activated receptor signaling pathway1 PublicationIC:ComplexPortal
Biological Process positive regulation of adipose tissue development1 PublicationIC:ComplexPortal
Biological Process positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process regulation of cellular response to insulin stimulus1 PublicationIC:ComplexPortal
Biological Process regulation of DNA-templated transcription1 PublicationNAS:UniProtKB
Biological Process regulation of glucose metabolic processIEA:Ensembl
Biological Process regulation of lipid metabolic processISS:UniProtKB
Biological Process response to progesteroneIEA:Ensembl

Cellular Location

Nucleus

Involvement in disease

Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation.

PTM