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Rabbit Anti-SRC2 Recombinant Antibody (D2X4M) (CBMAB-CP3087-LY)

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Datasheet
SDS
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Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Rabbit
Clone
D2X4M
Application
WB, IP, CIP
Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly1440 of human SRC-2 protein.
Specificity
Human, Monkey
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
SRC2
Entrez Gene ID
Human10499
Monkey693455
UniProt ID
HumanQ15596
MonkeyF6XNZ4
Function
Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed:8670870, PubMed:23508108, PubMed:9430642).
Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) (PubMed:8670870, PubMed:23508108, PubMed:9430642).
Required with NCOA1 to control energy balance between white and brown adipose tissues (PubMed:8670870, PubMed:23508108, PubMed:9430642).
Critical regulator of glucose metabolism regulation, acts as RORA coactivator to specifically modulate G6PC1 expression (PubMed:8670870, PubMed:23508108, PubMed:9430642).
Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3 (PubMed:23508108).
Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-ARNTL/BMAL1 heterodimer (By similarity).
Biological Process
Biological Process cellular response to hormone stimulusManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cellular response to Thyroglobulin triiodothyronineIEA:Ensembl
Biological Process circadian regulation of gene expressionISS:UniProtKB
Biological Process locomotor rhythmIEA:Ensembl
Biological Process mRNA transcription by RNA polymerase II1 PublicationIC:ComplexPortal
Biological Process negative regulation of transcription by RNA polymerase IIIEA:Ensembl
Biological Process peroxisome proliferator activated receptor signaling pathway1 PublicationIC:ComplexPortal
Biological Process positive regulation of adipose tissue development1 PublicationIC:ComplexPortal
Biological Process positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process regulation of cellular response to insulin stimulus1 PublicationIC:ComplexPortal
Biological Process regulation of DNA-templated transcription1 PublicationNAS:UniProtKB
Biological Process regulation of glucose metabolic processIEA:Ensembl
Biological Process regulation of lipid metabolic processISS:UniProtKB
Biological Process response to progesteroneIEA:Ensembl
Cellular Location
Nucleus
Involvement in disease
Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation.
PTM
Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation.
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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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