SSPN

This gene encodes a member of the dystrophin-glycoprotein complex (DGC). The DGC spans the sarcolemma and is comprised of dystrophin, syntrophin, alpha- and beta-dystroglycans and sarcoglycans. The DGC provides a structural link between the subsarcolemmal cytoskeleton and the extracellular matrix of muscle cells. Two alternatively spliced transcript variants that encode different protein isoforms have been described.

Sarcospan

Component of the dystrophin-glycoprotein complex (DGC), a complex that spans the muscle plasma membrane and forms a link between the F-actin cytoskeleton and the extracellular matrix. Preferentially associates with the sarcoglycan subcomplex of the DGC.

Biological Process cell adhesionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process muscle contractionManual Assertion Based On ExperimentTAS:ProtInc

Cell membrane
Cell membrane, sarcolemma
Postsynaptic cell membrane
Also found in myotendinous junctions and in the postsynaptic membrane of neuromuscular junctions.

Cytoplasmic: 1-53
Helical: 54-74
Extracellular: 75-86
Helical: 87-107
Cytoplasmic: 108-122
Helical: 123-143
Extracellular: 144-193
Helical: 194-214
Cytoplasmic: 215-243