STX4

STX4 (Syntaxin 4) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Sertoli-Sertoli Cell Junction Dynamics. Gene Ontology (GO) annotations related to this gene include SNARE binding and sphingomyelin phosphodiesterase activator activity. An important paralog of this gene is STX1B.Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones.

STX4

Plasma membrane t-SNARE that mediates docking of transport vesicles (By similarity).
Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane (By similarity).
In neurons, recruited at neurite tips to membrane domains rich in the phospholipid 1-oleoyl-2-palmitoyl-PC (OPPC) which promotes neurite tip surface expression of the dopamine transporter SLC6A3/DAT by facilitating fusion of SLC6A3-containing transport vesicles with the plasma membrane (By similarity).
Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes and in docking of synaptic vesicles at presynaptic active zones (By similarity).

Biological Process cellular response to interferon-gammaIEA:Ensembl
Biological Process cellular response to oxidative stressManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cornified envelope assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process exocytosisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process intracellular protein transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process long-term synaptic potentiationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process organelle fusionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of catalytic activityManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of cell adhesionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of cell population proliferationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of chemotaxisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of eosinophil degranulationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of immunoglobulin productionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of insulin secretion involved in cellular response to glucose stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of protein localization to cell surfaceManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of protein localization to plasma membraneManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein localization to cell surfaceISS:UniProtKB
Biological Process regulation of exocytosisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of extrinsic apoptotic signaling pathway via death domain receptorsManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process SNARE complex assemblyIEA:Ensembl
Biological Process synaptic vesicle fusion to presynaptic active zone membraneManual Assertion Based On ExperimentIBA:GO_Central
Biological Process vesicle dockingManual Assertion Based On ExperimentIBA:GO_Central
Biological Process vesicle fusionManual Assertion Based On ExperimentIBA:GO_Central

Cell membrane
Cell projection, neuron projection
Localizes to neurite tips in neuronal cells.

Cytoplasmic: 1-275
Helical: 276-296
Extracellular: 297