STX8

The gene is a member of the syntaxin family. The encoded protein is involved in protein trafficking from early to late endosomes via vesicle fusion and exocytosis. A related pseudogene has been identified on chromosome 12. Alternative splicing results in multiple transcript variants.

Full Name

STX8

Function

Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER.

Biological Process

Biological Process cellular response to interferon-gammaIEA:Ensembl
Biological Process early endosome to late endosome transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process endosome to lysosome transportIEA:Ensembl
Biological Process intracellular protein transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of protein localization to plasma membraneManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process vesicle dockingManual Assertion Based On ExperimentIBA:GO_Central
Biological Process vesicle fusionManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Membrane
Preferentially associated with the early endosome. To a lesser extent, also present in late endosome, the plasma membrane and coated pits (By similarity).

Topology

Cytoplasmic: 1-215
Helical: 216-232
Vesicular: 233-236

PTM

Ubiquitinated by HECTD3.