SYP (Concentrate)

Full Name

synaptophysin

Function

Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity (By similarity).

Biological Process

Biological Process cellular response to organic substanceIEA:Ensembl
Biological Process endocytosisISS:UniProtKB
Biological Process regulation of long-term neuronal synaptic plasticityISS:UniProtKB
Biological Process regulation of neuronal synaptic plasticityIBA:GO_Central1 Publication
Biological Process regulation of opioid receptor signaling pathwayISS:UniProtKB
Biological Process regulation of short-term neuronal synaptic plasticityISS:UniProtKB
Biological Process regulation of synaptic vesicle exocytosisIEA:Ensembl
Biological Process synaptic vesicle endocytosisIEA:Ensembl
Biological Process synaptic vesicle maturationNAS:UniProtKB1 Publication
Biological Process synaptic vesicle membrane organizationNAS:UniProtKB1 Publication

Cellular Location

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
Synapse, synaptosome

Involvement in disease

Intellectual developmental disorder, X-linked 96 (XLID96):
A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.

Topology

Cytoplasmic: 1-25
Helical: 26-49
Vesicular: 50-106
Helical: 107-130
Cytoplasmic: 131-137
Helical: 138-161
Vesicular: 162-199
Helical: 200-223
Cytoplasmic: 224-313

PTM

Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.
Phosphorylated by SRC.