TAL1

TAL1 (MALAT1 Antisense Transcript) is an RNA Gene, and is affiliated with the ncRNA class.

TAL BHLH Transcription Factor 1, Erythroid Differentiation Factor

Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity).

Biological Process basophil differentiationIEP:BHF-UCL1 Publication
Biological Process cell fate commitmentISS:BHF-UCL
Biological Process embryonic hemopoiesisISS:UniProtKB
Biological Process erythrocyte differentiationIMP:BHF-UCL1 Publication
Biological Process hemopoiesisISS:BHF-UCL
Biological Process megakaryocyte differentiationIEP:BHF-UCL1 Publication
Biological Process positive regulation of cell divisionIMP:BHF-UCL1 Publication
Biological Process positive regulation of chromatin organizationIMP:BHF-UCL1 Publication
Biological Process positive regulation of DNA-templated transcriptionIDA:UniProtKB1 Publication
Biological Process positive regulation of erythrocyte differentiationIDA:UniProtKB1 Publication
Biological Process positive regulation of mitotic cell cycleIMP:BHF-UCL1 Publication
Biological Process positive regulation of protein-containing complex assemblyIDA:BHF-UCL1 Publication
Biological Process positive regulation of transcription by RNA polymerase IIIDA:BHF-UCL1 Publication
Biological Process regulation of transcription by RNA polymerase IIISS:BHF-UCL

Nucleus

A chromosomal aberration involving TAL1 may be a cause of some T-cell acute lymphoblastic leukemias (T-ALL). Translocation t(1;14)(p32;q11) with T-cell receptor alpha chain (TCRA) genes.

Phosphorylated on serine residues. Phosphorylation of Ser-122 is strongly stimulated by hypoxia (By similarity).
Ubiquitinated; subsequent to hypoxia-dependent phosphorylation of Ser-122, ubiquitination targets the protein for rapid degradation via the ubiquitin system. This process may be characteristic for microvascular endothelial cells, since it could not be observed in large vessel endothelial cells (By similarity).