TAL1
TAL1 (MALAT1 Antisense Transcript) is an RNA Gene, and is affiliated with the ncRNA class.
Full Name
TAL BHLH Transcription Factor 1, Erythroid Differentiation Factor
Function
Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity).
Biological Process
Biological Process basophil differentiationIEP:BHF-UCL1 Publication
Biological Process cell fate commitmentISS:BHF-UCL
Biological Process embryonic hemopoiesisISS:UniProtKB
Biological Process erythrocyte differentiationIMP:BHF-UCL1 Publication
Biological Process hemopoiesisISS:BHF-UCL
Biological Process megakaryocyte differentiationIEP:BHF-UCL1 Publication
Biological Process positive regulation of cell divisionIMP:BHF-UCL1 Publication
Biological Process positive regulation of chromatin organizationIMP:BHF-UCL1 Publication
Biological Process positive regulation of DNA-templated transcriptionIDA:UniProtKB1 Publication
Biological Process positive regulation of erythrocyte differentiationIDA:UniProtKB1 Publication
Biological Process positive regulation of mitotic cell cycleIMP:BHF-UCL1 Publication
Biological Process positive regulation of protein-containing complex assemblyIDA:BHF-UCL1 Publication
Biological Process positive regulation of transcription by RNA polymerase IIIDA:BHF-UCL1 Publication
Biological Process regulation of transcription by RNA polymerase IIISS:BHF-UCL
Biological Process cell fate commitmentISS:BHF-UCL
Biological Process embryonic hemopoiesisISS:UniProtKB
Biological Process erythrocyte differentiationIMP:BHF-UCL1 Publication
Biological Process hemopoiesisISS:BHF-UCL
Biological Process megakaryocyte differentiationIEP:BHF-UCL1 Publication
Biological Process positive regulation of cell divisionIMP:BHF-UCL1 Publication
Biological Process positive regulation of chromatin organizationIMP:BHF-UCL1 Publication
Biological Process positive regulation of DNA-templated transcriptionIDA:UniProtKB1 Publication
Biological Process positive regulation of erythrocyte differentiationIDA:UniProtKB1 Publication
Biological Process positive regulation of mitotic cell cycleIMP:BHF-UCL1 Publication
Biological Process positive regulation of protein-containing complex assemblyIDA:BHF-UCL1 Publication
Biological Process positive regulation of transcription by RNA polymerase IIIDA:BHF-UCL1 Publication
Biological Process regulation of transcription by RNA polymerase IIISS:BHF-UCL
Cellular Location
Nucleus
Involvement in disease
A chromosomal aberration involving TAL1 may be a cause of some T-cell acute lymphoblastic leukemias (T-ALL). Translocation t(1;14)(p32;q11) with T-cell receptor alpha chain (TCRA) genes.
PTM
Phosphorylated on serine residues. Phosphorylation of Ser-122 is strongly stimulated by hypoxia (By similarity).
Ubiquitinated; subsequent to hypoxia-dependent phosphorylation of Ser-122, ubiquitination targets the protein for rapid degradation via the ubiquitin system. This process may be characteristic for microvascular endothelial cells, since it could not be observed in large vessel endothelial cells (By similarity).
Ubiquitinated; subsequent to hypoxia-dependent phosphorylation of Ser-122, ubiquitination targets the protein for rapid degradation via the ubiquitin system. This process may be characteristic for microvascular endothelial cells, since it could not be observed in large vessel endothelial cells (By similarity).
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Anti-TAL1 antibodies
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Target: TAL1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2TL242
Application*: IH, IF, IP, WB
Target: TAL1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2TL170
Application*: IH, IP
Target: TAL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse
Clone: SCL-C
Application*: WB
Target: TAL1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-1779
Application*: WB, IC
Target: TAL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-6131
Application*: CI
Target: TAL1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: BTL73
Application*: WB, IH
Target: TAL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5194
Application*: WB, F, IH, IF, P
Target: TAL1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-4668
Application*: WB, IH, IF, IP
Target: TAL1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-4667
Application*: IH, IP
Target: TAL1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat, Mouse
Clone: CBYJT-1928
Application*: WB, IP, IF, E
Target: TAL1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat, Mouse
Clone: CBYJT-1927
Application*: WB, IP, IF, E
Target: TAL1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat, Mouse
Clone: CBYJT-1926
Application*: WB, IP, IF, E
Target: TAL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-1925
Application*: WB, IH, IF, F
Target: TAL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-1924
Application*: WB, IF, F
Target: TAL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-1923
Application*: WB, IF, F
Target: TAL1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-1922
Application*: F, IF, WB
Target: TAL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-1921
Application*: F, IF, WB
Target: TAL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Zebrafish
Clone: CBXS-4073
Application*: WB, IF
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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