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Mouse Anti-TAL1 Recombinant Antibody (CBXS-5194) (CBMAB-S2411-CQ)

This product is a mouse antibody that recognizes TAL1. The antibody CBXS-5194 can be used for immunoassay techniques such as: WB, FC, IHC, IF, IHC-P.
See all TAL1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-5194
Antibody Isotype
IgG1
Application
WB, FC, IHC, IF, IHC-P

Basic Information

Immunogen
Recombinant full length human TAL1(NP_003180)
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TAL BHLH Transcription Factor 1, Erythroid Differentiation Factor
Introduction
TAL1 (MALAT1 Antisense Transcript) is an RNA Gene, and is affiliated with the ncRNA class.
Entrez Gene ID
6886
UniProt ID
P17542
Alternative Names
TAL BHLH Transcription Factor 1, Erythroid Differentiation Factor; Class A Basic Helix-Loop-Helix Protein 17; T-Cell Acute Lymphocytic Leukemia 1; T-Cell Leukemia/Lymphoma Protein 5; Stem Cell Protein; BHLHa17;
Function
Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity).
Biological Process
Biological Process basophil differentiationIEP:BHF-UCL1 Publication
Biological Process cell fate commitmentISS:BHF-UCL
Biological Process embryonic hemopoiesisISS:UniProtKB
Biological Process erythrocyte differentiationIMP:BHF-UCL1 Publication
Biological Process hemopoiesisISS:BHF-UCL
Biological Process megakaryocyte differentiationIEP:BHF-UCL1 Publication
Biological Process positive regulation of cell divisionIMP:BHF-UCL1 Publication
Biological Process positive regulation of chromatin organizationIMP:BHF-UCL1 Publication
Biological Process positive regulation of DNA-templated transcriptionIDA:UniProtKB1 Publication
Biological Process positive regulation of erythrocyte differentiationIDA:UniProtKB1 Publication
Biological Process positive regulation of mitotic cell cycleIMP:BHF-UCL1 Publication
Biological Process positive regulation of protein-containing complex assemblyIDA:BHF-UCL1 Publication
Biological Process positive regulation of transcription by RNA polymerase IIIDA:BHF-UCL1 Publication
Biological Process regulation of transcription by RNA polymerase IIISS:BHF-UCL
Cellular Location
Nucleus
Involvement in disease
A chromosomal aberration involving TAL1 may be a cause of some T-cell acute lymphoblastic leukemias (T-ALL). Translocation t(1;14)(p32;q11) with T-cell receptor alpha chain (TCRA) genes.
PTM
Phosphorylated on serine residues. Phosphorylation of Ser-122 is strongly stimulated by hypoxia (By similarity).
Ubiquitinated; subsequent to hypoxia-dependent phosphorylation of Ser-122, ubiquitination targets the protein for rapid degradation via the ubiquitin system. This process may be characteristic for microvascular endothelial cells, since it could not be observed in large vessel endothelial cells (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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