Mouse Anti-TAL1 Recombinant Antibody (CBXS-4668) (CBMAB-S0246-CQ)

Name: Mouse Anti-TAL1 Recombinant Antibody (CBXS-4668)
SKU: CBMAB-S0246-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

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Basic Information

Host Animal

Mouse

Clone

CBXS-4668

Application

WB, IHC, IF, IP

Immunogen

Recombinant TAL-1 protein

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

TAL BHLH Transcription Factor 1, Erythroid Differentiation Factor

Introduction

TAL1 (MALAT1 Antisense Transcript) is an RNA Gene, and is affiliated with the ncRNA class.

Entrez Gene ID

6886

UniProt ID

P17542

Alternative Names

TAL BHLH Transcription Factor 1, Erythroid Differentiation Factor; Class A Basic Helix-Loop-Helix Protein 17; T-Cell Acute Lymphocytic Leukemia 1; T-Cell Leukemia/Lymphoma Protein 5; Stem Cell Protein; BHLHa17;

Function

Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity).

Biological Process

Biological Process basophil differentiationIEP:BHF-UCL1 Publication
Biological Process cell fate commitmentISS:BHF-UCL
Biological Process embryonic hemopoiesisISS:UniProtKB
Biological Process erythrocyte differentiationIMP:BHF-UCL1 Publication
Biological Process hemopoiesisISS:BHF-UCL
Biological Process megakaryocyte differentiationIEP:BHF-UCL1 Publication
Biological Process positive regulation of cell divisionIMP:BHF-UCL1 Publication
Biological Process positive regulation of chromatin organizationIMP:BHF-UCL1 Publication
Biological Process positive regulation of DNA-templated transcriptionIDA:UniProtKB1 Publication
Biological Process positive regulation of erythrocyte differentiationIDA:UniProtKB1 Publication
Biological Process positive regulation of mitotic cell cycleIMP:BHF-UCL1 Publication
Biological Process positive regulation of protein-containing complex assemblyIDA:BHF-UCL1 Publication
Biological Process positive regulation of transcription by RNA polymerase IIIDA:BHF-UCL1 Publication
Biological Process regulation of transcription by RNA polymerase IIISS:BHF-UCL

Cellular Location

Nucleus

Involvement in disease

A chromosomal aberration involving TAL1 may be a cause of some T-cell acute lymphoblastic leukemias (T-ALL). Translocation t(1;14)(p32;q11) with T-cell receptor alpha chain (TCRA) genes.

PTM

Phosphorylated on serine residues. Phosphorylation of Ser-122 is strongly stimulated by hypoxia (By similarity).
Ubiquitinated; subsequent to hypoxia-dependent phosphorylation of Ser-122, ubiquitination targets the protein for rapid degradation via the ubiquitin system. This process may be characteristic for microvascular endothelial cells, since it could not be observed in large vessel endothelial cells (By similarity).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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