TFF2
Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. The encoded protein inhibits gastric acid secretion. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq]
Full Name
trefoil factor 2
Function
Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains (By similarity).
Biological Process
Biological Process chemokine-mediated signaling pathwaySource:GO_Central1 Publication
Biological Process maintenance of gastrointestinal epitheliumSource:GO_Central1 Publication
Biological Process negative regulation of gastric acid secretionSource:GO_Central1 Publication
Biological Process maintenance of gastrointestinal epitheliumSource:GO_Central1 Publication
Biological Process negative regulation of gastric acid secretionSource:GO_Central1 Publication
Cellular Location
Secreted
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Anti-TFF2 antibodies
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Target: TFF2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2A10
Application*: WB, E
Target: TFF2
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: GE16C
Application*: IH, IF
Target: TFF2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-1543
Application*: WB
Target: TFF2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4G7C3
Application*: WB, IP, IF, P, F, E
Target: TFF2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Rat
Clone: CBXS-5638
Application*: WB, IC, P, C, E, IP, IF, F
Target: Tff2
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBYJT-2684
Application*: WB, IC, P, E
Target: TFF2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJT-2682
Application*: SE, E, WB
Target: TFF2
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: CBYJT-2681
Application*: IH, IC, IF
Target: TFF2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-2680
Application*: E, WB, P, IF, IC, F
Target: TFF2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-2679
Application*: WB
Target: TFF2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJT-2678
Application*: E, WB
Target: TFF2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3696
Application*: F
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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