TOM1

This gene was identified as a target of the v-myb oncogene. The encoded protein shares its N-terminal domain in common with proteins associated with vesicular trafficking at the endosome. It is recruited to the endosomes by its interaction with endofin. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

TOM1 Gene(Protein Coding) Target Of Myb1 Membrane Trafficking Protein

Adapter protein that plays a role in the intracellular membrane trafficking of ubiquitinated proteins, thereby participating in autophagy, ubiquitination-dependent signaling and receptor recycling pathways (PubMed:14563850, PubMed:15047686, PubMed:23023224, PubMed:25588840, PubMed:26320582, PubMed:31371777).
Acts as a MYO6/Myosin VI adapter protein that targets MYO6 to endocytic structures (PubMed:23023224).
Together with MYO6, required for autophagosomal delivery of endocytic cargo, the maturation of autophagosomes and their fusion with lysosomes (PubMed:23023224).
MYO6 links TOM1 with autophagy receptors, such as TAX1BP1; CALCOCO2/NDP52 and OPTN (PubMed:31371777).
Binds to polyubiquitinated proteins via its GAT domain (PubMed:14563850).
In a complex with TOLLIP, recruits ubiquitin-conjugated proteins onto early endosomes (PubMed:15047686).
The Tom1-Tollip complex may regulate endosomal trafficking by linking polyubiquitinated proteins to clathrin (PubMed:14563850, PubMed:15047686).
Mediates clathrin recruitment to early endosomes by ZFYVE16 (PubMed:15657082).
Modulates binding of TOLLIP to phosphatidylinositol 3-phosphate (PtdIns3P) via binding competition; the association with TOLLIP may favor the release of TOLLIP from endosomal membranes, allowing TOLLIP to commit to cargo trafficking (PubMed:26320582).
Acts as a phosphatidylinositol 5-phosphate (PtdIns5P) effector by binding to PtdIns5P, thereby regulating endosomal maturation (PubMed:25588840).
PtdIns5P-dependent recruitment to signaling endosomes may block endosomal maturation (PubMed:25588840).
Also inhibits Toll-like receptor (TLR) signaling and participates in immune receptor recycling (PubMed:15047686, PubMed:26320582).

Biological Process autophagosome-lysosome fusion Source:UniProtKB1 Publication
Biological Process endocytosis Source:UniProtKB1 Publication
Biological Process endosomal transport Source:UniProtKB2 Publications
Biological Process positive regulation of autophagosome maturation Source:UniProtKB1 Publication
Biological Process protein transport Source:UniProtKB1 Publication
Biological Process regulation of endosome organization Source:UniProtKB1 Publication
Biological Process signal transduction Source:GO_Central1 Publication
Biological Process substrate localization to autophagosome Source:UniProtKB1 Publication

Cytoplasm
Endosome membrane
Early endosome membrane
Localized to endo/exosomal vesicles (PubMed:31263572).
Enriched on signaling endosomes (PubMed:25588840).
Recruited to early endosomes by TOLLIP and by PtdIns5P (PubMed:15047686, PubMed:25588840, PubMed:26320582).

Immunodeficiency 85 (IMD85):
An autosomal dominant immunologic disorder characterized by early-onset autoimmunity and features of combined immunodeficiency such as hypogammaglobulinemia and abnormal T-cell function. Clinical manifestations include atopic eczema and recurrent respiratory infections in the first decade of life, autoimmune enteropathy, growth failure, autoimmune oligoarthritis, interstitial pneumonitis, and EBV viremia.

Monoubiquitinated.