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TSSK2

TSSK2 belongs to a family of serine/threonine kinases highly expressed in testis (Hao et al., 2004 [PubMed 15044604]).[supplied by OMIM

Full Name

testis-specific serine kinase 2

Function

Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates TSKS at 'Ser-288' and SPAG16. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body.

Biological Process

Biological Process intracellular signal transduction Source:GO_Central1 Publication
Biological Process peptidyl-serine phosphorylation Source:Ensembl
Biological Process protein autophosphorylation Source:UniProtKB1 Publication
Biological Process protein phosphorylation Source:UniProtKB
Biological Process spermatid development Source:UniProtKB

Cellular Location

Cytoplasm
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole
Present in the cytoplasm of elongating spermatids. In spermatozoa, localizes in the equatorial segment, neck, the midpiece and in a specific sperm head compartment (By similarity).
In spermatids, concentrates in centrioles during flagellogenesis

PTM

Autophosphorylated.
Ubiquitinated; HSP90 activity negatively regulates ubiquitination and degradation.

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Anti-TSSK2 antibodies

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Mouse Anti-TSSK2 Recombinant Antibody (1F6) (CBMAB-A9592-LY)

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Target: TSSK2

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 1F6

Application*: WB, E

Mouse Anti-TSSK2 Recombinant Antibody (1E12) (CBMAB-A9591-LY)

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Target: TSSK2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 1E12

Application*: WB, E

Mouse Anti-TSSK2 Recombinant Antibody (CBYJT-5101) (CBMAB-T4679-YJ)

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Target: TSSK2

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBYJT-5101

Application*: WB

Mouse Anti-TSSK2 Recombinant Antibody (CBYJT-5100) (CBMAB-T4678-YJ)

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Target: TSSK2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBYJT-5100

Application*: IF, SE, E, WB, P

Mouse Anti-TSSK2 Recombinant Antibody (CBYJT-5099) (CBMAB-T4677-YJ)

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Target: TSSK2

Host: Mouse

Antibody Isotype: IgG, κ

Specificity: Human

Clone: CBYJT-5099

Application*: E, WB

Human Recombinant TSSK2, Active protein, GST Tag (V2LY-0526-LY7452)

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Target: TSSK2

Expressed Host: Baculovirus-Insect Cells

Sequence: Amino Acid: Full Length

Tag: GST Tag

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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