TSSK2

TSSK2 belongs to a family of serine/threonine kinases highly expressed in testis (Hao et al., 2004 [PubMed 15044604]).[supplied by OMIM

Full Name

testis-specific serine kinase 2

Function

Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates TSKS at 'Ser-288' and SPAG16. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body.

Biological Process

Biological Process intracellular signal transduction Source:GO_Central1 Publication
Biological Process peptidyl-serine phosphorylation Source:Ensembl
Biological Process protein autophosphorylation Source:UniProtKB1 Publication
Biological Process protein phosphorylation Source:UniProtKB
Biological Process spermatid development Source:UniProtKB

Cellular Location

Cytoplasm
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole
Present in the cytoplasm of elongating spermatids. In spermatozoa, localizes in the equatorial segment, neck, the midpiece and in a specific sperm head compartment (By similarity).
In spermatids, concentrates in centrioles during flagellogenesis

PTM

Autophosphorylated.
Ubiquitinated; HSP90 activity negatively regulates ubiquitination and degradation.

Anti-TSSK2 antibodies

Mouse Anti-TSSK2 Recombinant Antibody (CBYJT-5099) (CBMAB-T4677-YJ)

Datasheet

SDS

Target: TSSK2

Host: Mouse

Antibody Isotype: IgG, κ

Specificity: Human

Clone: CBYJT-5099

Application*: E, WB

Mouse Anti-TSSK2 Recombinant Antibody (CBYJT-5100) (CBMAB-T4678-YJ)

Datasheet

SDS

Target: TSSK2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBYJT-5100

Application*: IF, SE, E, WB, P

Mouse Anti-TSSK2 Recombinant Antibody (CBYJT-5101) (CBMAB-T4679-YJ)

Datasheet

SDS

Target: TSSK2

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBYJT-5101

Application*: WB

Mouse Anti-TSSK2 Recombinant Antibody (1E12) (CBMAB-A9591-LY)

Datasheet

SDS

Target: TSSK2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 1E12

Application*: WB, E

Mouse Anti-TSSK2 Recombinant Antibody (1F6) (CBMAB-A9592-LY)

Datasheet

SDS

Target: TSSK2

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 1F6

Application*: WB, E

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)