TYK2

This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008]
Full Name
TYK2 Gene(Protein Coding) Tyrosine Kinase 2
Function
Non-receptor kinase involved in various processes including cell growth, development, cell migration, innate and adaptive immunity (PubMed:10995743, PubMed:10542297).
Plays both structural and catalytic roles in numerous cytokines and interferons signaling (PubMed:10542297).
Associates with cytokine and growth factor receptors and activate STAT family members including STAT1, STAT3, STAT4 or STAT6 (PubMed:10542297, PubMed:7638186).
The heterodimeric cytokine receptor complexes are composed of a TYK2-associated receptor chain (IFNAR1, IL12RB1, IL10RB or IL13RA1) which serves as the signal transducing chain harboring STAT docking sites once phosphorylated by TYK2, and a second receptor chain associated either with JAK1 or JAK2 (PubMed:10542297, PubMed:7526154, PubMed:25762719).
In turn, recruited STATs are phosphorylated, form homo- and heterodimers, translocate to the nucleus, and regulate cytokine/growth factor responsive genes. Negatively regulates STAT3 activity by promototing phosphorylation at a specific tyrosine that differs from the site used for signaling (PubMed:29162862).
Biological Process
Cellular response to virus1 PublicationIC:ComplexPortal
Cytokine-mediated signaling pathwayTAS:Reactome
Immune response1 PublicationIC:ComplexPortal
Intracellular signal transductionIEA:InterPro
Positive regulation of interferon-gamma productionManual Assertion Based On ExperimentIDA:ComplexPortal
Positive regulation of interleukin-17 production1 PublicationIC:ComplexPortal
Positive regulation of natural killer cell proliferationManual Assertion Based On ExperimentIDA:ComplexPortal
Positive regulation of NK T cell proliferationManual Assertion Based On ExperimentIDA:ComplexPortal
Positive regulation of receptor signaling pathway via JAK-STATManual Assertion Based On ExperimentIDA:ComplexPortal
Positive regulation of T cell proliferationManual Assertion Based On ExperimentIDA:ComplexPortal
Positive regulation of T-helper 17 type immune response1 PublicationIC:ComplexPortal
Protein phosphorylationManual Assertion Based On ExperimentTAS:ProtInc
Type I interferon signaling pathwayTAS:Reactome
Type III interferon signaling pathway1 PublicationIC:ComplexPortal
Cellular Location
cytoplasm
cytoskeleton
cytosol
extracellular exosome
interleukin-12 receptor complex
interleukin-23 receptor complex
nucleus
plasma membrane
Involvement in disease
Immunodeficiency 35 (IMD35):
A primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE.
PTM
Phosphorylated (PubMed:7638186).
Phosphorylations at Tyr-1054 and Tyr-1055 induce kinase activation (PubMed:8702790).
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Anti-TYK2 antibodies

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Mouse Anti-TYK2 Recombinant Antibody (6H1) (CBMAB-A9685-LY)

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Target: TYK2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 6H1
Application*: WB, E
Datasheet SDS

Mouse Anti-TYK2 Recombinant Antibody (6G12) (CBMAB-A9684-LY)

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Target: TYK2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 6G12
Application*: WB, E
Datasheet SDS

Mouse Anti-TYK2 Recombinant Antibody (5A4) (CBMAB-A9683-LY)

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Target: TYK2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 5A4
Application*: WB, E
Datasheet SDS

Rabbit Anti-TYK2 Recombinant Antibody (CBYJT-5506) (CBMAB-T5122-YJ)

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Target: TYK2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Monkey
Clone: CBYJT-5506
Application*: WB, IP
Datasheet SDS

Mouse Anti-TYK2 Recombinant Antibody (CBYJT-5505) (CBMAB-T5121-YJ)

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Target: TYK2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-5505
Application*: E, WB
Datasheet SDS

Mouse Anti-TYK2 Recombinant Antibody (CBYJT-5504) (CBMAB-T5120-YJ)

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Target: TYK2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJT-5504
Application*: E, WB
Datasheet SDS

Mouse Anti-TYK2 Recombinant Antibody (CBYJT-5503) (CBMAB-T5119-YJ)

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Target: TYK2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJT-5503
Application*: E, IF, IH, IP, WB
Datasheet SDS

Mouse Anti-TYK2 Recombinant Antibody (CBYJT-5502) (CBMAB-T5118-YJ)

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Target: TYK2
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: CBYJT-5502
Application*: WB
Datasheet SDS

Mouse Anti-TYK2 Recombinant Antibody (CBYJT-5501) (CBMAB-T5117-YJ)

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Target: TYK2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-5501
Application*: E, WB
Datasheet SDS

Mouse Anti-TYK2 Recombinant Antibody (CBWJT-019) (CBMAB-0477-WJ)

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Target: TYK2
Host: Mouse
Specificity: Human
Clone: CBWJT-019
Application*: WB, IC, P, IH-F, E
Datasheet SDS

Mouse Anti-TYK2 Recombinant Antibody (CBT1259) (V2LY-0625-LY2897)

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Target: TYK2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT1259
Application*: WB, E
Datasheet SDS

Mouse Anti-Tyk2 Recombinant Antibody (CBT2927) (V2LY-0625-LY2140)

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Target: Tyk2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2927
Application*: WB
Datasheet SDS

Mouse Anti-TYK2 Recombinant Antibody (8G8E9,8G9H5,8G8B3) (CBMAB-AO1050LY)

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Target: TYK2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 8G8E9,8G9H5,8G8B3
Application*: WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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