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Mouse Anti-TYK2 Recombinant Antibody (CBT1259) (V2LY-0625-LY2897)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT1259
Antibody Isotype
IgG
Application
WB, ELISA

Basic Information

Immunogen
Purified recombinant fragment of Tyk 2 expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
ELISA1:10,000
WB1:500-1:2,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Buffer
BSA, Glycerol
Preservative
Sodium azide
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
TYK2 Gene(Protein Coding) Tyrosine Kinase 2
Entrez Gene ID
7297
Function
Non-receptor kinase involved in various processes including cell growth, development, cell migration, innate and adaptive immunity (PubMed:10995743, PubMed:10542297).
Plays both structural and catalytic roles in numerous cytokines and interferons signaling (PubMed:10542297).
Associates with cytokine and growth factor receptors and activate STAT family members including STAT1, STAT3, STAT4 or STAT6 (PubMed:10542297, PubMed:7638186).
The heterodimeric cytokine receptor complexes are composed of a TYK2-associated receptor chain (IFNAR1, IL12RB1, IL10RB or IL13RA1) which serves as the signal transducing chain harboring STAT docking sites once phosphorylated by TYK2, and a second receptor chain associated either with JAK1 or JAK2 (PubMed:10542297, PubMed:7526154, PubMed:25762719).
In turn, recruited STATs are phosphorylated, form homo- and heterodimers, translocate to the nucleus, and regulate cytokine/growth factor responsive genes. Negatively regulates STAT3 activity by promototing phosphorylation at a specific tyrosine that differs from the site used for signaling (PubMed:29162862).
Biological Process
Cellular response to virus1 PublicationIC:ComplexPortal
Cytokine-mediated signaling pathwayTAS:Reactome
Immune response1 PublicationIC:ComplexPortal
Intracellular signal transductionIEA:InterPro
Positive regulation of interferon-gamma productionManual Assertion Based On ExperimentIDA:ComplexPortal
Positive regulation of interleukin-17 production1 PublicationIC:ComplexPortal
Positive regulation of natural killer cell proliferationManual Assertion Based On ExperimentIDA:ComplexPortal
Positive regulation of NK T cell proliferationManual Assertion Based On ExperimentIDA:ComplexPortal
Positive regulation of receptor signaling pathway via JAK-STATManual Assertion Based On ExperimentIDA:ComplexPortal
Positive regulation of T cell proliferationManual Assertion Based On ExperimentIDA:ComplexPortal
Positive regulation of T-helper 17 type immune response1 PublicationIC:ComplexPortal
Protein phosphorylationManual Assertion Based On ExperimentTAS:ProtInc
Type I interferon signaling pathwayTAS:Reactome
Type III interferon signaling pathway1 PublicationIC:ComplexPortal
Cellular Location
cytoplasm
cytoskeleton
cytosol
extracellular exosome
interleukin-12 receptor complex
interleukin-23 receptor complex
nucleus
plasma membrane
Involvement in disease
Immunodeficiency 35 (IMD35):
A primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE.
PTM
Phosphorylated (PubMed:7638186).
Phosphorylations at Tyr-1054 and Tyr-1055 induce kinase activation (PubMed:8702790).
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For research use only. Not intended for any clinical use.

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