UPP1

The 2 known types of pyrimidine nucleoside phosphorylases, uridine phosphorylase (UP; EC 2.4.2.3) and thymidine phosphorylase (TP; EC 2.4.2.4), in the presence of orthophosphate, catalyze the reversible phosphorolysis of uridine and thymidine or deoxyuridine, respectively, to free bases and ribose-1-phosphate or deoxyribose-1-phosphate. Pyrimidine nucleoside phosphorylases can add ribose or deoxyribose to pyrimidine bases to form nucleosides that can be incorporated into RNA or DNA (Watanabe and Uchida, 1995 [PubMed 7488099]).[supplied by OMIM

Full Name

uridine phosphorylase 1

Function

Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate (PubMed:7488099).
The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis

Biological Process

Biological Process cellular response to glucose starvation Source:Ensembl
Biological Process CMP catabolic process Source:Ensembl
Biological Process dCMP catabolic process Source:Ensembl
Biological Process dTMP catabolic process Source:Ensembl
Biological Process dUMP catabolic process Source:Ensembl
Biological Process nucleobase-containing compound metabolic process Source:ProtInc1 Publication
Biological Process UMP catabolic process Source:Ensembl
Biological Process UMP salvage Source:UniProtKB-UniPathway
Biological Process uridine catabolic process Source:UniProtKB1 Publication

Cellular Location

cytosol
nucleoplasm