WTAP

The Wilms tumor suppressor gene WT1 appears to play a role in both transcriptional and posttranscriptional regulation of certain cellular genes. This gene encodes a WT1-associating protein, which is a ubiquitously expressed nuclear protein. Like WT1 protein, this protein is localized throughout the nucleoplasm as well as in speckles and partially colocalizes with splicing factors. Alternative splicing of this gene results in three transcript variants, two of which encode the same isoform. [provided by RefSeq]
Full Name
WTAP
Function
Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755).
Required for accumulation of METTL3 and METTL14 to nuclear speckle (PubMed:24316715, PubMed:24407421, PubMed:24981863).
Acts as a mRNA splicing regulator (PubMed:12444081).
Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability (PubMed:17088532).
Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes (PubMed:17095724).
Biological Process
Biological Process cell cycle Source:UniProtKB-KW
Biological Process mRNA methylation Source:UniProtKB3 Publications
Biological Process mRNA processing Source:UniProtKB-KW
Biological Process regulation of alternative mRNA splicing, via spliceosome Source:UniProtKB1 Publication
Biological Process RNA splicing Source:UniProtKB-KW
Cellular Location
Nucleus speckle
Nucleus, nucleoplasm
Cytoplasm
Mainly nuclear with some fraction located in the cytoplasm. ZC3H13 is required to anchor component of the MACOM subcomplex, such as VIRMA, in the nucleus.
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Anti-WTAP antibodies

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Mouse Anti-WTAP Monoclonal Antibody (1B11) (CBMAB-0306-LY)

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Target: WTAP
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1B11
Application*: IP, E
Datasheet SDS

Mouse Anti-WTAP Monoclonal Antibody (1A4) (CBMAB-0305-LY)

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Target: WTAP
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1A4
Application*: IP, E
Datasheet SDS

Mouse Anti-WTAP Recombinant Antibody (CBT3541) (V2LY-0625-LY317)

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Target: WTAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: CBT3541
Application*: WB, IH, IC, F
Datasheet SDS

Mouse Anti-WTAP Recombinant Antibody (CBT4318) (V2LY-0625-LY247)

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Target: WTAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4318
Application*: IH, F
Datasheet SDS

Mouse Anti-WTAP Recombinant Antibody (6H3) (CBMAB-W0370-WJ)

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Target: WTAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6H3
Application*: WB, IH
Datasheet SDS

Mouse Anti-WTAP Recombinant Antibody (6C3) (CBMAB-W0369-WJ)

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Target: WTAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6C3
Application*: WB, IH
Datasheet SDS

Mouse Anti-WTAP Recombinant Antibody (2C4) (CBMAB-W0356-WJ)

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Target: WTAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2C4
Application*: WB
Datasheet SDS

Mouse Anti-WTAP Recombinant Antibody (CBWJW-097) (CBMAB-W0248-WJ)

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Target: WTAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJW-097
Application*: WB, IH
Datasheet SDS

Mouse Anti-WTAP Recombinant Antibody (CBWJW-082) (CBMAB-W0234-WJ)

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Target: WTAP
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: CBWJW-082
Application*: E, WB, IH
Datasheet SDS

Mouse Anti-WTAP Recombinant Antibody (CBWJW-081) (CBMAB-W0233-WJ)

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Target: WTAP
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBWJW-081
Application*: WB, P
Datasheet SDS

Mouse Anti-WTAP Recombinant Antibody (CBWJW-041) (CBMAB-W0195-WJ)

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Target: WTAP
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBWJW-041
Application*: SE, P, E, WB
Datasheet SDS

Mouse Anti-WTAP Recombinant Antibody (6B6B8) (CBMAB-W0139-WJ)

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Target: WTAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6B6B8
Application*: E, WB, P, F
Datasheet SDS

Mouse Anti-WTAP Recombinant Antibody (6B6B6) (CBMAB-W0138-WJ)

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Target: WTAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: 6B6B6
Application*: E, WB, P, IF, F
Datasheet SDS

Mouse Anti-WTAP Recombinant Antibody (CBWJW-211) (CBMAB-W0106-WJ)

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Target: WTAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBWJW-211
Application*: E, IF, IH, WB, siRNA
Datasheet SDS

Mouse Anti-WTAP Recombinant Antibody (12G6) (CBMAB-W0005-WJ)

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Target: WTAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 12G6
Application*: P, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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