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Mouse Anti-WTAP Recombinant Antibody (CBT3541) (V2LY-0625-LY317)


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Summary

Host Animal
Mouse
Specificity
Human, Monkey
Clone
CBT3541
Antibody Isotype
IgG1
Application
WB, IHC, ICC, FC

Basic Information

Immunogen
Purified recombinant fragment of human WTAP (AA: 91-201) expressed in E. Coli.
Host Species
Mouse
Specificity
Human, Monkey
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
IHC-P1:200-1:1,000
ICC1:200-1:1,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
WTAP
Entrez Gene ID
9589
Function
Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755).
Required for accumulation of METTL3 and METTL14 to nuclear speckle (PubMed:24316715, PubMed:24407421, PubMed:24981863).
Acts as a mRNA splicing regulator (PubMed:12444081).
Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability (PubMed:17088532).
Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes (PubMed:17095724).
Biological Process
Biological Process cell cycle Source:UniProtKB-KW
Biological Process mRNA methylation Source:UniProtKB3 Publications
Biological Process mRNA processing Source:UniProtKB-KW
Biological Process regulation of alternative mRNA splicing, via spliceosome Source:UniProtKB1 Publication
Biological Process RNA splicing Source:UniProtKB-KW
Cellular Location
Nucleus speckle
Nucleus, nucleoplasm
Cytoplasm
Mainly nuclear with some fraction located in the cytoplasm. ZC3H13 is required to anchor component of the MACOM subcomplex, such as VIRMA, in the nucleus.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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