Sign in or Register   Sign in or Register
  |  

Mouse Anti-ACADS Recombinant Antibody (V2-179178) (CBMAB-A0435-YC)

Provided herein is a Mouse monoclonal antibody against Human Acyl-CoA Dehydrogenase Short Chain. The antibody can be used for immunoassay techniques, such as WB, ELISA, ICC, IF.
See all ACADS antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-179178
Antibody Isotype
IgG2a, κ
Application
WB, ELISA, ICC, IF

Basic Information

Immunogen
Recombinant human ACADS (25-412aa) purified from E. coli
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:1,000
IF(ICC)1:100

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH7.4, 10% Glycerol
Preservative
0.02% sodium azide
Concentration
1 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Acyl-CoA Dehydrogenase Short Chain
Introduction
ACADS is a tetrameric mitochondrial flavoprotein, which is a member of the acyl-CoA dehydrogenase family. This enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Mutations in this gene have been associated with short
Entrez Gene ID
35
UniProt ID
P16219
Alternative Names
Acyl-CoA Dehydrogenase Short Chain; Acyl-Coenzyme A Dehydrogenase, C-2 To C-3 Short Chain; Butyryl-CoA Dehydrogenase; SCAD; Short-Chain Specific Acyl-CoA Dehydrogenase, Mitochondrial; Mitochondrial Short-Chain Specific Acyl-CoA Dehydrogenase; Acyl-CoA Deh
Function
Short-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats (By similarity). The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (By similarity). Among the different mitochondrial acyl-CoA dehydrogenases, short-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 4 to 6 carbons long primary chains.
Biological Process
Butyrate catabolic process
Fatty acid beta-oxidation
Fatty acid beta-oxidation using acyl-CoA dehydrogenase
Cellular Location
Mitochondrion matrix
Involvement in disease
An inborn error of mitochondrial fatty acid beta-oxidation resulting in acute acidosis and muscle weakness in infants, and a form of lipid-storage myopathy in adults.

Yang, Z., He, M., Austin, J., Pfleger, J., & Abdellatif, M. (2021). Histone H3K9 butyrylation is regulated by dietary fat and stress via an Acyl-CoA dehydrogenase short chain-dependent mechanism. Molecular metabolism, 53, 101249.

Suzuki, Y., Ito, S., Otani, Y., Nishikawa, A., Eto, K., Hara, K., ... & Nagata, S. (2021). Unexpected elevation in valproic acid concentration and agranulocytosis in a patient with short-chain acyl-CoA dehydrogenase deficiency. Brain and Development, 43(5), 657-660.

Sojikul, L. (2020). To what extent does Acyl-CoA dehydrogenase short chain gene Affect the risk of heart related diseases. To what extent does Acyl-CoA dehydrogenase short chain gene Affect the risk of heart related diseases, 51(1), 5-5.

Adhikari, A. N., Currier, R. J., Tang, H., Turgeon, C. T., Nussbaum, R. L., Srinivasan, R., ... & Gallagher, R. (2020). Genomic Analysis of Historical Cases with Positive Newborn Screens for Short-Chain Acyl-CoA Dehydrogenase Deficiency Shows That a Validated Second-Tier Biochemical Test Can Replace Future Sequencing. International journal of neonatal screening, 6(2), 41.

Chen, Y., Chen, J., Zhang, C., Yang, S., Zhang, X., Liu, Y., & Su, Z. (2019). Deficiency in the short‐chain acyl‐CoA dehydrogenase protects mice against diet‐induced obesity and insulin resistance. The FASEB Journal, 33(12), 13722-13733.

Wolfe, L., Jethva, R., Oglesbee, D., & Vockley, J. (2018). Short-chain acyl-CoA dehydrogenase deficiency.

Nochi, Z., Olsen, R. K. J., & Gregersen, N. (2017). Short-chain acyl-CoA dehydrogenase deficiency: from gene to cell pathology and possible disease mechanisms. Journal of inherited metabolic disease, 40(5), 641-655.

Dessein, A. F., Fontaine, M., Curt, M. J. C., Briand, G., Sechter, C., Mention-Mulliez, K., ... & Vamecq, J. (2017). Fluxomic evidence for impaired contribution of short-chain acyl-CoA dehydrogenase to mitochondrial palmitate β-oxidation in symptomatic patients with ACADS gene susceptibility variants. Clinica Chimica Acta, 471, 101-106.

Chiplunkar, S., Bindu, P. S., Nagappa, M., Panikulam, B. B., Arvinda, H. R., Govindaraj, P., ... & Taly, A. B. (2017). Novel magnetic resonance imaging findings in a patient with short chain acyl CoA dehydrogenase deficiency. Metabolic brain disease, 32(4), 967-970.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-ACADS Recombinant Antibody (V2-179178)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare