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Mouse Anti-ADRM1 Recombinant Antibody (V2-611016) (CBMAB-A0169-LY)

The product is antibody recognizes ADRM1. The antibody 3C6 immunoassay techniques such as: WB, ELISA.
See all ADRM1 antibodies
Published Data
Fig.1 Cisplatin induces a protein complex formation between p‐ΔNp63α and Rpn13 in wild type ΔNp63α cells and between Rpn13 and LKB1 in ΔNp63α‐S385G cells.
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Fig.2 Immunoblot analysis of the protein levels of RPN13 and TFs potentially regulating RPN13 expression.
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Fig.3 RPN13 binds to NOS2 and targets it to proteasome-dependent degradation.
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Fig.4 siRNA silencing of RPN13 rescues NOS2 expression and activity in HNSCC cells upon cisplatin exposure.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-611016
Antibody Isotype
IgG2b, κ
Application
WB, ELISA

Basic Information

Immunogen
ADRM1 (AAH17245.1, 18 a.a. ~ 407 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
IF(ICC)10 μg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH7.4
Preservative
None
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Adhesion Regulating Molecule 1
Introduction
The protein encoded by this gene is an integral plasma membrane protein which promotes cell adhesion. The encoded protein is thought to undergo O-linked glycosylation. Expression of this gene has been shown to be induced by gamma interferon in some cancer cells. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq]
Entrez Gene ID
11047
UniProt ID
Q16186
Alternative Names
ARM1; GP110; MGC29536; Rpn13
Function
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Within the complex, functions as a proteasomal ubiquitin receptor. Engages and activates 19S-associated deubiquitinases UCHL5 and PSMD14 during protein degradation. UCHL5 reversibly associate with the 19S regulatory particle whereas PSMD14 is an intrinsic subunit of the proteasome lid subcomplex.
Biological Process
Proteasome assembly
Protein deubiquitination
Transcription elongation from RNA polymerase II promoter
Ubiquitin-dependent protein catabolic process
Cellular Location
Nucleus; Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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