Mouse Anti-APLP2 Recombinant Antibody (4B5) (CBMAB-A3086-YC)

Name: Mouse Anti-APLP2 Recombinant Antibody (4B5)
SKU: CBMAB-A3086-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

4B5

Application

ELISA

Immunogen

Partial recombinant corresponding to aa 41-150 from human APLP2 (AAH00373) with GST tag.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Preservative

None

Concentration

Batch dependent

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Amyloid Beta Precursor Like Protein 2

Introduction

APLP2 is amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-te

Entrez Gene ID

334

UniProt ID

Q06481

Alternative Names

Amyloid Beta Precursor Like Protein 2; Amyloid Beta (A4) Precursor-Like Protein 2; CDEI Box-Binding Protein; APLP-2; APPL2; CDEBP;

Function

May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity).

Biological Process

Cellular protein metabolic process Source: Reactome
G protein-coupled receptor signaling pathway Source: UniProtKB
Platelet degranulation Source: Reactome
Post-translational protein modification Source: Reactome

Cellular Location

Nucleus; Cell membrane

Topology

Extracellular: 32-692 aa
Helical: 693-716 aa
Cytoplasmic: 717-763 aa

PTM

The BPTI/Kunitz inhibitor domain is O-glycosylated.

Poelaert, B. J., Knoche, S. M., Larson, A. C., Pandey, P., Seshacharyulu, P., Khan, N., ... & Solheim, J. C. (2021). Amyloid Precursor-like Protein 2 Expression Increases during Pancreatic Cancer Development and Shortens the Survival of a Spontaneous Mouse Model of Pancreatic Cancer. Cancers, 13(7), 1535.

Dahiya, N. (2020). Amyloid precursor-like protein 2 interacts with claudin-7 and affects ovarian cancer cell survival. Future science OA, 6(4), FSO457.

Truong, P. H. (2019). Investigating the role of Amyloid Precursor-Like Protein 2 in Motor Neurone Disease (Doctoral dissertation).

Roisman, L. C., Han, S., Chuei, M. J., Connor, A. R., & Cappai, R. (2019). The crystal structure of amyloid precursor‐like protein 2 E2 domain completes the amyloid precursor protein family. The FASEB Journal, 33(4), 5076-5081.

Sliker, B. (2019). Human Leukocyte Antigen (HLA) Class I Molecule Components and Amyloid Precursor-Like Protein 2 (APLP2): Roles in Pancreatic Cancer Cell Migration.

Truong, P. H., Ciccotosto, G. D., & Cappai, R. (2019). Analysis of Motor Function in Amyloid Precursor-Like Protein 2 Knockout Mice: The Effects of Ageing and Sex. Neurochemical research, 44(6), 1356-1366.

Sliker, B. H., Goetz, B. T., Peters, H. L., Poelaert, B. J., Borgstahl, G. E., & Solheim, J. C. (2019). Beta 2-microglobulin regulates amyloid precursor-like protein 2 expression and the migration of pancreatic cancer cells. Cancer biology & therapy, 20(6), 931-940.

Truong, P. H., Ciccotosto, G. D., Merson, T. D., Spoerri, L., Chuei, M. J., Ayers, M., ... & Cappai, R. (2019). Amyloid precursor protein and amyloid precursor‐like protein 2 have distinct roles in modulating myelination, demyelination, and remyelination of axons. Glia, 67(3), 525-538.

Chen, Y., Wang, H., Tan, C., Yan, Y., Shen, J., Huang, Q., ... & Chen, J. (2018). Expression of amyloid precursor-like protein 2 (APLP2) in glioblastoma is associated with patient prognosis. Folia Neuropathol, 56, 30-38.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

APLP2 Matched Antibody Pair (090) (CAT#: APMAB-090LY)

Related Products

APLP2 Matched Antibody Pair (090) (CAT#: APMAB-090LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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