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Mouse Anti-APLP2 Recombinant Antibody (4B5) (CBMAB-A3086-YC)

Provided herein is a Mouse monoclonal antibody against Human Amyloid Beta Precursor Like Protein 2. The antibody can be used for immunoassay techniques, such as ELISA.
See all APLP2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4B5
Antibody Isotype
IgG2b, κ
Application
ELISA

Basic Information

Immunogen
Partial recombinant corresponding to aa 41-150 from human APLP2 (AAH00373) with GST tag.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Amyloid Beta Precursor Like Protein 2
Introduction
APLP2 is amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-te
Entrez Gene ID
334
UniProt ID
Q06481
Alternative Names
Amyloid Beta Precursor Like Protein 2; Amyloid Beta (A4) Precursor-Like Protein 2; CDEI Box-Binding Protein; APLP-2; APPL2; CDEBP;
Function
May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity).
Biological Process
Cellular protein metabolic process Source: Reactome
G protein-coupled receptor signaling pathway Source: UniProtKB
Platelet degranulation Source: Reactome
Post-translational protein modification Source: Reactome
Cellular Location
Nucleus; Cell membrane
Topology
Extracellular: 32-692 aa
Helical: 693-716 aa
Cytoplasmic: 717-763 aa
PTM
The BPTI/Kunitz inhibitor domain is O-glycosylated.

Poelaert, B. J., Knoche, S. M., Larson, A. C., Pandey, P., Seshacharyulu, P., Khan, N., ... & Solheim, J. C. (2021). Amyloid Precursor-like Protein 2 Expression Increases during Pancreatic Cancer Development and Shortens the Survival of a Spontaneous Mouse Model of Pancreatic Cancer. Cancers, 13(7), 1535.

Dahiya, N. (2020). Amyloid precursor-like protein 2 interacts with claudin-7 and affects ovarian cancer cell survival. Future science OA, 6(4), FSO457.

Truong, P. H. (2019). Investigating the role of Amyloid Precursor-Like Protein 2 in Motor Neurone Disease (Doctoral dissertation).

Roisman, L. C., Han, S., Chuei, M. J., Connor, A. R., & Cappai, R. (2019). The crystal structure of amyloid precursor‐like protein 2 E2 domain completes the amyloid precursor protein family. The FASEB Journal, 33(4), 5076-5081.

Sliker, B. (2019). Human Leukocyte Antigen (HLA) Class I Molecule Components and Amyloid Precursor-Like Protein 2 (APLP2): Roles in Pancreatic Cancer Cell Migration.

Truong, P. H., Ciccotosto, G. D., & Cappai, R. (2019). Analysis of Motor Function in Amyloid Precursor-Like Protein 2 Knockout Mice: The Effects of Ageing and Sex. Neurochemical research, 44(6), 1356-1366.

Sliker, B. H., Goetz, B. T., Peters, H. L., Poelaert, B. J., Borgstahl, G. E., & Solheim, J. C. (2019). Beta 2-microglobulin regulates amyloid precursor-like protein 2 expression and the migration of pancreatic cancer cells. Cancer biology & therapy, 20(6), 931-940.

Truong, P. H., Ciccotosto, G. D., Merson, T. D., Spoerri, L., Chuei, M. J., Ayers, M., ... & Cappai, R. (2019). Amyloid precursor protein and amyloid precursor‐like protein 2 have distinct roles in modulating myelination, demyelination, and remyelination of axons. Glia, 67(3), 525-538.

Chen, Y., Wang, H., Tan, C., Yan, Y., Shen, J., Huang, Q., ... & Chen, J. (2018). Expression of amyloid precursor-like protein 2 (APLP2) in glioblastoma is associated with patient prognosis. Folia Neuropathol, 56, 30-38.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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