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APLP2 Matched Antibody Pair (090) (APMAB-090LY)

This antibody pair set can be used for detecting and quantifying protein level of human APLP2.
See all APLP2 antibodies

Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-APLP2 polyclonal antibody, 100 ug
Detection Antibody
Anti-APLP2 Mouse monoclonal, IgG2b antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer's disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Alternative Names
Amyloid Beta Precursor Like Protein 2; Amyloid Beta (A4) Precursor-Like Protein 2; CDEI Box-Binding Protein; APLP-2; APPL2; CDEBP;
Entrez Gene ID
334
UniProt ID
Q06481

Poelaert, B. J., Knoche, S. M., Larson, A. C., Pandey, P., Seshacharyulu, P., Khan, N., ... & Solheim, J. C. (2021). Amyloid Precursor-like Protein 2 Expression Increases during Pancreatic Cancer Development and Shortens the Survival of a Spontaneous Mouse Model of Pancreatic Cancer. Cancers, 13(7), 1535.

Dahiya, N. (2020). Amyloid precursor-like protein 2 interacts with claudin-7 and affects ovarian cancer cell survival. Future science OA, 6(4), FSO457.

Truong, P. H. (2019). Investigating the role of Amyloid Precursor-Like Protein 2 in Motor Neurone Disease (Doctoral dissertation).

Roisman, L. C., Han, S., Chuei, M. J., Connor, A. R., & Cappai, R. (2019). The crystal structure of amyloid precursor‐like protein 2 E2 domain completes the amyloid precursor protein family. The FASEB Journal, 33(4), 5076-5081.

Sliker, B. (2019). Human Leukocyte Antigen (HLA) Class I Molecule Components and Amyloid Precursor-Like Protein 2 (APLP2): Roles in Pancreatic Cancer Cell Migration.

Truong, P. H., Ciccotosto, G. D., & Cappai, R. (2019). Analysis of Motor Function in Amyloid Precursor-Like Protein 2 Knockout Mice: The Effects of Ageing and Sex. Neurochemical research, 44(6), 1356-1366.

Sliker, B. H., Goetz, B. T., Peters, H. L., Poelaert, B. J., Borgstahl, G. E., & Solheim, J. C. (2019). Beta 2-microglobulin regulates amyloid precursor-like protein 2 expression and the migration of pancreatic cancer cells. Cancer biology & therapy, 20(6), 931-940.

Truong, P. H., Ciccotosto, G. D., Merson, T. D., Spoerri, L., Chuei, M. J., Ayers, M., ... & Cappai, R. (2019). Amyloid precursor protein and amyloid precursor‐like protein 2 have distinct roles in modulating myelination, demyelination, and remyelination of axons. Glia, 67(3), 525-538.

Chen, Y., Wang, H., Tan, C., Yan, Y., Shen, J., Huang, Q., ... & Chen, J. (2018). Expression of amyloid precursor-like protein 2 (APLP2) in glioblastoma is associated with patient prognosis. Folia Neuropathol, 56, 30-38.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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