Rabbit Anti-ARHGAP26 Recombinant Antibody (CBLG1-2473) (CBMAB-G1261-LY)

Name: Rabbit Anti-ARHGAP26 Recombinant Antibody (CBLG1-2473)
SKU: CBMAB-G1261-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

CBLG1-2473

Application

Immunogen

Synthetic peptide corresponding to residues surrounding Lys261 of human GRAF1 protein.

Specificity

Mouse, Rat, Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

HEPES, pH 7.5, 150 mM NaCl, 100 µg/ml BSA, 50% glycerol

Preservative

0.02% sodium azide

Concentration

Batch dependent

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Rho GTPase Activating Protein 26

Introduction

Interaction of a cell with the extracellular matrix triggers integrin cell surface receptors to begin signaling cascades that regulate the organization of the actin-cytoskeleton. One of the proteins involved in these cascades is focal adhesion kinase. The protein encoded by this gene is a GTPase activating protein that binds to focal adhesion kinase and mediates the activity of the GTP binding proteins RhoA and Cdc42. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). Multiple transcript variants encoding different isoforms have been found for this gene.

Entrez Gene ID

Human	23092
Mouse	71302
Rat	307459

UniProt ID

Human	Q9UNA1
Mouse	Q6ZQ82
Rat	Q9ERC1

Function

GTPase-activating protein for RHOA and CDC42.

Biological Process

Actin cytoskeleton organization Source: UniProtKB
Nervous system development Source: UniProtKB
Regulation of small GTPase mediated signal transduction Source: Reactome
Signal transduction Source: InterPro

Cellular Location

Cytoskeleton; Focal adhesion. Colocalizes with actin stress fibers and cortical actin structures.

Involvement in disease

Leukemia, juvenile myelomonocytic (JMML): The gene represented in this entry is involved in disease pathogenesis. A chromosomal translocation t(5;11)(q31;q23) with KMT2A/MLL1 has been found in leukemic cells from JMML patients, also carrying inactivating mutations on the second allele (PubMed:10908648). An aggressive pediatric myelodysplastic syndrome/myeloproliferative disorder characterized by malignant transformation in the hematopoietic stem cell compartment with proliferation of differentiated progeny. Patients have splenomegaly, enlarged lymph nodes, rashes, and hemorrhages.

Li, M., Ye, L., Ye, X., Wang, S., Zhang, H., Liu, J., & Hong, H. (2019). Hypoxia‐induced ARHGAP26 deficiency inhibits the proliferation and migration of human ductus arteriosus smooth muscle cell through activating RhoA‐ROCK‐PTEN pathway. Journal of cellular biochemistry, 120(6), 10106-10117.

Chen, X., Chen, S., Li, Y., Gao, Y., Huang, S., Li, H., & Zhu, Y. (2019). SMURF1-mediated ubiquitination of ARHGAP26 promotes ovarian cancer cell invasion and migration. Experimental & molecular medicine, 51(4), 1-12.

Jiang, C., Gong, W., Chen, R., Ke, H., Qu, X., Yang, W., & Cheng, Z. (2018). RhoA/ROCK/ARHGAP26 signaling in the eutopic and ectopic endometrium is involved in clinical characteristics of adenomyosis. Journal of International Medical Research, 46(12), 5019-5029.

Bartels, F., Prüss, H., & Finke, C. (2018). Anti-ARHGAP26 autoantibodies are associated with isolated cognitive impairment. Frontiers in neurology, 9, 656.

Wallwitz, U., Brock, S., Schunck, A., Wildemann, B., Jarius, S., & Hoffmann, F. (2017). From dizziness to severe ataxia and dysarthria: new cases of anti-Ca/ARHGAP26 autoantibody-associated cerebellar ataxia suggest a broad clinical spectrum. Journal of neuroimmunology, 309, 77-81.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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