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Mouse Anti-AVP Recombinant Antibody (CBYC-A905) (CBMAB-A4213-YC)

Provided herein is a Mouse monoclonal antibody against Human Arginine Vasopressin. The antibody can be used for immunoassay techniques, such as ELISA.
See all AVP antibodies

Summary

Host Animal
Mouse
Specificity
Mouse
Clone
CBYC-A905
Antibody Isotype
IgG1, κ
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Amino acids 111-160 mapping near the C-terminus of AVP of mouse origin.
Specificity
Mouse
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
ELISA1:100-1:1,000
IF(ICC)1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Arginine Vasopressin
Introduction
AVP is a member of the vasopressin/oxytocin family and preproprotein that is proteolytically processed to generate multiple protein products. These products include the neuropeptide hormone arginine vasopressin, and two other peptides, neurophysin 2 and c
Entrez Gene ID
551
UniProt ID
P01185
Alternative Names
Arginine Vasopressin; Prepro-Arginine-Vasopressin-Neurophysin II; Antidiuretic Hormone; Neurohypophyseal; Prepro-AVP-NP II; Copeptin; AVP-NPII; ARVP;
Function
Neurophysin 2: Specifically binds vasopressin.
Arg-vasopressin: Has a direct antidiuretic action on the kidney, it also causes vasoconstriction of the peripheral vessels. Acts by binding to vasopressin receptors (V1bR/AVPR1B, V1aR/AVPR1A, and V2R/AVPR2) (PubMed:18174156).
Biological Process
Cell-cell signaling Source: ProtInc
ERK1 and ERK2 cascade Source: UniProtKB
Generation of precursor metabolites and energy Source: ProtInc
G protein-coupled receptor signaling pathway Source: Reactome
Grooming behavior Source: Ensembl
Hyperosmotic salinity response Source: Ensembl
Locomotory behavior Source: Ensembl
Maternal aggressive behavior Source: Ensembl
Maternal behavior Source: Ensembl
Membrane organization Source: Reactome
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
Negative regulation of female receptivity Source: Ensembl
Negative regulation of inflammatory response to antigenic stimulus Source: Reactome
Negative regulation of release of cytochrome c from mitochondria Source: UniProtKB
Negative regulation of transmission of nerve impulse Source: Ensembl
Penile erection Source: Ensembl
Positive regulation of cell growth Source: Ensembl
Positive regulation of cell population proliferation Source: Ensembl
Positive regulation of cellular pH reduction Source: Ensembl
Positive regulation of cytosolic calcium ion concentration Source: Ensembl
Positive regulation of gene expression Source: UniProtKB
Positive regulation of glutamate secretion Source: Ensembl
Positive regulation of peptidyl-serine phosphorylation Source: UniProtKB
Positive regulation of prostaglandin biosynthetic process Source: Ensembl
Positive regulation of systemic arterial blood pressure Source: Ensembl
Positive regulation of vasoconstriction Source: Ensembl
Protein kinase C signaling Source: UniProtKB
Regulation of renal sodium excretion Source: Ensembl
Renal water homeostasis Source: Reactome
Response to ethanol Source: Ensembl
Response to nicotine Source: Ensembl
Response to testosterone Source: Ensembl
Signal transduction Source: UniProtKB
Social behavior Source: Ensembl
Vasoconstriction Source: UniProtKB-KW
Water transport Source: ProtInc
Cellular Location
Secreted
Involvement in disease
Diabetes insipidus, neurohypophyseal (NDI): A disease characterized by persistent thirst, polydipsia and polyuria. Affected individuals are apparently normal at birth, but characteristically develop symptoms of vasopressin deficiency during childhood.

Grieb, Z. A., Ross, A. P., McCann, K. E., Lee, S., Welch, M., Gomez, M. G., ... & Albers, H. E. (2021). Sex-dependent effects of social status on the regulation of arginine-vasopressin (AVP) V1a, oxytocin (OT), and serotonin (5-HT) 1A receptor binding and aggression in Syrian hamsters (Mesocricetus auratus). Hormones and Behavior, 127, 104878.

Kawaguchi, Y., Hagiwara, D., Miyata, T., Hodai, Y., Kurimoto, J., Takagi, H., ... & Arima, H. (2020). Endoplasmic reticulum chaperone BiP/GRP78 knockdown leads to autophagy and cell death of arginine vasopressin neurons in mice. Scientific reports, 10(1), 1-13.

Zhao, J., Lei, Y., Yang, Y., Gao, H., Gai, Z., & Li, X. (2020). Metoprolol alleviates arginine vasopressin-induced cardiomyocyte hypertrophy by upregulating the AKT1–SERCA2 cascade in H9C2 cells. Cell & bioscience, 10, 1-12.

Zhou, M. F., Feng, Z. P., Ou, Y. C., Peng, J. J., Li, K., Gong, H. D., ... & Qi, S. T. (2019). Endoplasmic reticulum stress induces apoptosis of arginine vasopressin neurons in central diabetes insipidus via PI3K/Akt pathway. CNS neuroscience & therapeutics, 25(5), 562-574.

Ross, A. P., McCann, K. E., Larkin, T. E., Song, Z., Grieb, Z. A., Huhman, K. L., & Albers, H. E. (2019). Sex-dependent effects of social isolation on the regulation of arginine-vasopressin (AVP) V1a, oxytocin (OT) and serotonin (5HT) 1a receptor binding and aggression. Hormones and behavior, 116, 104578.

Largeau, B., Le Tilly, O., Sautenet, B., Gandonnière, C. S., Barin-Le Guellec, C., & Ehrmann, S. (2019). Arginine vasopressin and posterior reversible encephalopathy syndrome pathophysiology: the missing link?. Molecular neurobiology, 56(10), 6792-6806.

Kompier, N. F., Keysers, C., Gazzola, V., Lucassen, P. J., & Krugers, H. J. (2019). Early life adversity and adult social behavior: focus on arginine vasopressin and oxytocin as potential mediators. Frontiers in behavioral neuroscience, 13, 143.

Sandgren, J. A., Deng, G., Linggonegoro, D. W., Scroggins, S. M., Perschbacher, K. J., Nair, A. R., ... & Grobe, J. L. (2018). Arginine vasopressin infusion is sufficient to model clinical features of preeclampsia in mice. JCI insight, 3(19).

Sims, C. A., Guan, Y., Bergey, M., Jaffe, R., Holmes-Maguire, L., Martin, N., & Reilly, P. (2017). Arginine vasopressin, copeptin, and the development of relative AVP deficiency in hemorrhagic shock. The American Journal of Surgery, 214(4), 589-595.

Terranova, J. I., Ferris, C. F., & Albers, H. E. (2017). Sex differences in the regulation of offensive aggression and dominance by arginine-vasopressin. Frontiers in endocrinology, 8, 308.

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For research use only. Not intended for any clinical use.

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