Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Mouse Anti-BGN Recombinant Antibody (2E6-D1) (CBMAB-A0756-LY)


See all BGN antibodies
Online Inquiry

Summary

Host Animal
Mouse
Specificity
Human
Clone
2E6-D1
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
BGN (AAH02416.1, 1 a.a. ~ 368 a.a) full-length recombinant protein with GST tag.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
biglycan
Introduction
The protein encoded by this gene is a small cellular or pericellular matrix proteoglycan that is closely related in structure to two other small proteoglycans, decorin and fibromodulin. The encoded protein and decorin are thought to be the result of a gene duplication. Decorin contains one attached glycosaminoglycan chain, while this protein probably contains two chains. For this reason, this protein is called biglycan. This protein is thought to function in connective tissue metabolism by binding to collagen fibrils and transfering growth factor-beta. It may promote neuronal survival. This gene is a candidate gene for the Happle syndrome. [provided by RefSeq]
Entrez Gene ID
633
UniProt ID
P21810
Alternative Names
DSPG1; PG-S1; PGI; SLRR1A
Function
May be involved in collagen fiber assembly.
Biological Process
Articular cartilage development Source: Ensembl
Blood vessel remodeling Source: Ensembl
Bone development Source: Ensembl
Chondroitin sulfate biosynthetic process Source: Reactome
Chondroitin sulfate catabolic process Source: Reactome
Dermatan sulfate biosynthetic process Source: Reactome
Extracellular matrix organization Source: Reactome
Peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan Source: Ensembl
Cellular Location
Extracellular matrix
Involvement in disease
Meester-Loeys syndrome (MRLS): An X-linked, thoracic aortic aneurysm syndrome characterized by early-onset, severe aortic aneurysm and dissection. Other recurrent findings include hypertelorism, pectus deformity, joint hypermobility, contractures, and mild skeletal dysplasia.
Spondyloepimetaphyseal dysplasia, X-linked (SEMDX): An X-linked recessive bone disease characterized by severe short-trunk dwarfism, brachydactyly, metaphyseal flaring of lower extremities, short and broad long bone diaphyses, moderate platyspondyly, normal facies, and normal intelligence.
PTM
The two attached glycosaminoglycan chains can be either chondroitin sulfate or dermatan sulfate.
More Infomation

Shao, C., Cheng, C., Shao, Q., & Chen, B. (2021). Identification and Validation of Biglycan as Prognosis and Therapy Markers for Patients with Stomach Adenocarcinoma. International Journal of General Medicine, 14, 3497.

Salimi, H., Suzuki, A., Habibi, H., Orita, K., Hori, Y., Yabu, A., ... & Nakamura, H. (2021). Biglycan expression and its function in human ligamentum flavum. Scientific reports, 11(1), 1-13.

Hua, R., Ni, Q., Eliason, T. D., Han, Y., Gu, S., Nicolella, D. P., ... & Jiang, J. X. (2020). Biglycan and chondroitin sulfate play pivotal roles in bone toughness via retaining bound water in bone mineral matrix. Matrix Biology, 94, 95-109.

Scuruchi, M., Potì, F., Rodríguez-Carrio, J., Campo, G. M., & Mandraffino, G. (2020). Biglycan and atherosclerosis: Lessons from high cardiovascular risk conditions. Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids, 1865(2), 158545.

Zhao, S. F., Yin, X. J., Zhao, W. J., Liu, L. C., & Wang, Z. P. (2020). Biglycan as a potential diagnostic and prognostic biomarker in multiple human cancers. Oncology letters, 19(3), 1673-1682.

Schulz, G. B., Grimm, T., Sers, C., Riemer, P., Elmasry, M., Kirchner, T., ... & Horst, D. (2019, August). Prognostic value and association with epithelial-mesenchymal transition and molecular subtypes of the proteoglycan biglycan in advanced bladder cancer. In Urologic Oncology: Seminars and Original Investigations (Vol. 37, No. 8, pp. 530-e9). Elsevier.

Zhang, Y. J., Qing, Q., Zhang, Y. J., Ning, L. J., Cui, J., Yao, X., ... & Qin, T. W. (2019). Enhancement of tenogenic differentiation of rat tendon‐derived stem cells by biglycan. Journal of cellular physiology, 234(9), 15898-15910.

Guo, D., Zhang, W., Yang, H., Bi, J., Xie, Y., Cheng, B., ... & Chen, S. (2019). Celastrol induces necroptosis and ameliorates inflammation via targeting biglycan in human gastric carcinoma. International journal of molecular sciences, 20(22), 5716.

Liu, B., Xu, T., Xu, X., Cui, Y., & Xing, X. (2018). Biglycan promotes the chemotherapy resistance of colon cancer by activating NF-κB signal transduction. Molecular and cellular biochemistry, 449(1), 285-294.

Jacobsen, F., Kraft, J., Schroeder, C., Hube-Magg, C., Kluth, M., Lang, D. S., ... & Melling, N. (2017). Up-regulation of biglycan is associated with poor prognosis and PTEN deletion in patients with prostate cancer. Neoplasia, 19(9), 707-715.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-BGN Recombinant Antibody (2E6-D1)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quote Online Inquiry
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry