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Mouse Anti-CCDC101 Recombinant Antibody (0208) (CBMAB-0208-YC)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
0208
Antibody Isotype
IgG1, κ
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Amino acids 40-59 within an internal region of CCDC101 of human origin.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
ELISA1:100-1:1,000
IF(ICC)1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Coiled-coil domain containing 101
Introduction
CCDC101 (coiled-coil domain containing 101) is a 293 amino acid nuclear protein that plays a role in transcriptional regulation by functioning as a subunit of two histone acetyltransferase complexes: the ADA2A (TADA2A; MIM 602276)-containing (ATAC) complex and the SPT3 (SUPT3H; MIM 602947)-TAF9 (MIM 600822)-GCN5 (KAT2A; MIM 602301)/PCAF (KAT2B; MIM 602303) acetylase (STAGA) complex. Both of these complexes contain either GCN5 or PCAF, which are paralogous acetyltransferases.
Entrez Gene ID
112869
UniProt ID
Q96ES7
Alternative Names
CCDC101; FLJ32446; TDRD29
Function
Chromatin reader component of some histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes (PubMed:19103755, PubMed:20850016, PubMed:26421618, PubMed:21685874, PubMed:26578293).
SGF29 specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3) (PubMed:20850016, PubMed:26421618, PubMed:21685874, PubMed:26578293).
In the SAGA-type complexes, SGF29 is required to recruit complexes to H3K4me (PubMed:20850016).
Involved in the response to endoplasmic reticulum (ER) stress by recruiting the SAGA complex to H3K4me, thereby promoting histone H3 acetylation and cell survival (PubMed:23894581).
Biological Process
Establishment of protein localization to chromatin Source: UniProtKB
Histone acetylation Source: UniProtKB
Histone H3 acetylation Source: BHF-UCL
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

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