CCDC101

CCDC101 (coiled-coil domain containing 101) is a 293 amino acid nuclear protein that plays a role in transcriptional regulation by functioning as a subunit of two histone acetyltransferase complexes: the ADA2A (TADA2A; MIM 602276)-containing (ATAC) complex and the SPT3 (SUPT3H; MIM 602947)-TAF9 (MIM 600822)-GCN5 (KAT2A; MIM 602301)/PCAF (KAT2B; MIM 602303) acetylase (STAGA) complex. Both of these complexes contain either GCN5 or PCAF, which are paralogous acetyltransferases.

Full Name

Coiled-coil domain containing 101

Function

Chromatin reader component of some histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes (PubMed:19103755, PubMed:20850016, PubMed:26421618, PubMed:21685874, PubMed:26578293).
SGF29 specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3) (PubMed:20850016, PubMed:26421618, PubMed:21685874, PubMed:26578293).
In the SAGA-type complexes, SGF29 is required to recruit complexes to H3K4me (PubMed:20850016).
Involved in the response to endoplasmic reticulum (ER) stress by recruiting the SAGA complex to H3K4me, thereby promoting histone H3 acetylation and cell survival (PubMed:23894581).

Biological Process

Establishment of protein localization to chromatin Source: UniProtKB
Histone acetylation Source: UniProtKB
Histone H3 acetylation Source: BHF-UCL

Cellular Location

Nucleus