Rabbit Anti-CCR2 Recombinant Antibody (CBYY-C1131) (CBMAB-C2568-YY)

Rabbit

Human, Mouse

CBYY-C1131

IgG

FC, ICC, IHC, IP

A synthetic peptide corresponding to the N-terminal residues of the human C-C chemokine receptor type 2. MW: 42-52kD

Human, Mouse

IgG

Monoclonal

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Tissue culture supernatant

0.15M NaCl

Liquid

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

C-C Motif Chemokine Receptor 2

Key functional receptor for CCL2 but can also bind CCL7 and CCL12 (PubMed:8146186, PubMed:8048929, PubMed:23408426).
Its binding with CCL2 on monocytes and macrophages mediates chemotaxis and migration induction through the activation of the PI3K cascade, the small G protein Rac and lamellipodium protrusion (Probable). Also acts as a receptor for the beta-defensin DEFB106A/DEFB106B (PubMed:23938203).
Regulates the expression of T-cell inflammatory cytokines and T-cell differentiation, promoting the differentiation of T-cells into T-helper 17 cells (Th17) during inflammation (By similarity).
Facilitates the export of mature thymocytes by enhancing directional movement of thymocytes to sphingosine-1-phosphate stimulation and up-regulation of S1P1R expression; signals through the JAK-STAT pathway to regulate FOXO1 activity leading to an increased expression of S1P1R (By similarity).
Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity).
Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B (By similarity).
Mediates the recruitment of macrophages and monocytes to the injury site following brain injury (By similarity).
(Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection.

Blood vessel remodeling Source: BHF-UCL
Calcium-mediated signaling Source: GO_Central
Cell chemotaxis Source: GO_Central
Cellular calcium ion homeostasis Source: BHF-UCL
Cellular defense response Source: ProtInc
Cellular homeostasis Source: BHF-UCL
Chemokine-mediated signaling pathway Source: BHF-UCL
Chemotaxis Source: ProtInc
Cytokine-mediated signaling pathway Source: MGI
Dendritic cell chemotaxis Source: BHF-UCL
G protein-coupled receptor signaling pathway Source: Reactome
Immune response Source: GO_Central
Inflammatory response Source: GO_Central
Inflammatory response to wounding Source: UniProtKB
Macrophage migration Source: UniProtKB
Monocyte extravasation Source: UniProtKB
Negative regulation of adenylate cyclase activity Source: ProtInc
Negative regulation of angiogenesis Source: BHF-UCL
Negative regulation of eosinophil degranulation Source: BHF-UCL
Negative regulation of type 2 immune response Source: BHF-UCL
Positive regulation of alpha-beta T cell proliferation Source: BHF-UCL
Positive regulation of astrocyte chemotaxis Source: BHF-UCL
Positive regulation of CD8-positive, alpha-beta T cell extravasation Source: BHF-UCL
Positive regulation of cold-induced thermogenesis Source: YuBioLab
Positive regulation of cytosolic calcium ion concentration Source: GO_Central
Positive regulation of hematopoietic stem cell migration Source: BHF-UCL
Positive regulation of immune complex clearance by monocytes and macrophages Source: BHF-UCL
Positive regulation of inflammatory response Source: BHF-UCL
Positive regulation of interferon-gamma production Source: BHF-UCL
Positive regulation of interleukin-2 production Source: BHF-UCL
Positive regulation of monocyte chemotaxis Source: UniProtKB
Positive regulation of monocyte extravasation Source: BHF-UCL
Positive regulation of NMDA glutamate receptor activity Source: ARUK-UCL
Positive regulation of synaptic transmission, glutamatergic Source: UniProtKB
Positive regulation of T cell activation Source: BHF-UCL
Positive regulation of T cell chemotaxis Source: BHF-UCL
Positive regulation of T-helper 1 type immune response Source: BHF-UCL
Positive regulation of thymocyte migration Source: UniProtKB
Positive regulation of tumor necrosis factor production Source: BHF-UCL
Receptor signaling pathway via JAK-STAT Source: ProtInc
Regulation of inflammatory response Source: UniProtKB
Regulation of T cell cytokine production Source: UniProtKB
Regulation of T cell differentiation Source: UniProtKB
Regulation of vascular endothelial growth factor production Source: BHF-UCL
Response to wounding Source: ProtInc
Sensory perception of pain Source: UniProtKB
T-helper 17 cell chemotaxis Source: BHF-UCL
Viral process Source: UniProtKB-KW

Cell membrane. The chemoattractant receptors are distributed throughout the cell surface; after stimulation with a ligand, such as CCL2, they are rapidly recruited into microdomain clusters at the cell membrane.

Extracellular: 1-42
Helical: 43-70
Cytoplasmic: 71-80
Helical: 81-100
Extracellular: 101-114
Helical: 115-136
Cytoplasmic: 137-153
Helical: 154-178
Extracellular: 179-206
Helical: 207-226
Cytoplasmic: 227-243
Helical: 244-268
Extracellular: 269-285
Helical: 286-309
Cytoplasmic: 310-374

N-glycosylated.
Sulfation increases the affinity for both monomeric and dimeric CCL2 with stronger binding to the monomeric form (PubMed:11046064, PubMed:23408426). Binding of sulfated CCR2 to CCL2 promotes conversion of CCL2 from dimer to monomer (PubMed:11046064, PubMed:23408426).