• Home
  • CCT3
  • Mouse Anti-CCT3 Recombinant Antibody (1265)

Mouse Anti-CCT3 Recombinant Antibody (1265) (CBMAB-AP918LY)

See all CCT3 antibodies
Go to compare Compare Online Inquiry
Datasheet
SDS
Request for COA
Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Mouse
Clone
1265
Application
WB, IF
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human CCT3, different from the related mouse and rat sequences by one amino acid.
Host Species
Mouse
Specificity
Human, Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB0.1-0.5 μg/ml
IF(ICC)5 μg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, Trehalose
Preservative
0.05mg sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
Chaperonin Containing TCP1 Subunit 3
Introduction
CCT3 (Chaperonin Containing TCP1 Subunit 3) is a Protein Coding gene. Diseases associated with CCT3 include Spinocerebellar Ataxia 10 and Immature Cataract. Among its related pathways are Organelle biogenesis and maintenance and Chaperonin-mediated protein folding. Gene Ontology (GO) annotations related to this gene include unfolded protein binding.
Entrez Gene ID
Human7203
Mouse12462
UniProt ID
HumanP49368
MouseP80318
Function
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444).
The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444).
As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638).
The TRiC complex plays a role in the folding of actin and tubulin (Probable).
Biological Process
Binding of sperm to zona pellucida Source: Ensembl
Pore complex assembly Source: Ensembl
Positive regulation of establishment of protein localization to telomere Source: BHF-UCL
Positive regulation of protein localization to Cajal body Source: BHF-UCL
Positive regulation of telomerase RNA localization to Cajal body Source: BHF-UCL
Positive regulation of telomere maintenance via telomerase Source: BHF-UCL
Protein folding Source: FlyBase
Protein stabilization Source: BHF-UCL
Toxin transport Source: Ensembl
Cellular Location
Cytoplasm

Danni, X., Jiangzheng, Z., Huamao, S., Yinglian, P., Changcheng, Y., & Yanda, L. (2021). Chaperonin containing TCP1 subunit 3 (CCT3) promotes cisplatin resistance of lung adenocarcinoma cells through targeting the Janus kinase 2/signal transducers and activators of transcription 3 (JAK2/STAT3) pathway. Bioengineered, 12(1), 7335-7347.

Qian, T., Cui, L., Liu, Y., Cheng, Z., Quan, L., Zeng, T., ... & Si, C. (2020). High expression of chaperonin-containing TCP1 subunit 3 may induce dismal prognosis in multiple myeloma. The pharmacogenomics journal, 20(4), 563-573.

Qu, H., Zhu, F., Dong, H., Hu, X., & Han, M. (2020). Upregulation of CCT-3 induces breast cancer cell proliferation through miR-223 competition and Wnt/β-catenin signaling pathway activation. Frontiers in oncology, 10.

Hou, J. Y., Wu, H. Y., He, R. Q., Lin, P., Dang, Y. W., & Chen, G. (2019). Clinical and prognostic value of chaperonin containing T-complex 1 subunit 3 in hepatocellular carcinoma: a study based on microarray and RNA-sequencing with 4272 cases. Pathology-Research and Practice, 215(1), 177-194.

Li, L. J., Zhang, L. S., Han, Z. J., He, Z. Y., Chen, H., & Li, Y. M. (2017). Chaperonin containing TCP-1 subunit 3 is critical for gastric cancer growth. Oncotarget, 8(67), 111470.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-CCT3 Recombinant Antibody (1265)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-CCT3 Recombinant Antibody (CF065) (CAT#: CBMAB-FT392LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry
Request bulk or custom quote Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

online inquiry
Online Inquiry