Mouse Anti-CCT3 Recombinant Antibody (1265) (CBMAB-AP918LY)

Name: Mouse Anti-CCT3 Recombinant Antibody (1265)
SKU: CBMAB-AP918LY
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human, Mouse

Clone

1265

Antibody Isotype

IgG1

Application

WB, IF

Basic Information

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human CCT3, different from the related mouse and rat sequences by one amino acid.

Host Species

Mouse

Specificity

Human, Mouse

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	0.1-0.5 μg/ml
IF(ICC)	5 μg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

PBS, Trehalose

Preservative

0.05mg sodium azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Introduction

CCT3 (Chaperonin Containing TCP1 Subunit 3) is a Protein Coding gene. Diseases associated with CCT3 include Spinocerebellar Ataxia 10 and Immature Cataract. Among its related pathways are Organelle biogenesis and maintenance and Chaperonin-mediated protein folding. Gene Ontology (GO) annotations related to this gene include unfolded protein binding.

Entrez Gene ID

Human	7203
Mouse	12462

UniProt ID

Human	P49368
Mouse	P80318

Function

Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444).
The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444).
As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638).
The TRiC complex plays a role in the folding of actin and tubulin (Probable).

Biological Process

Binding of sperm to zona pellucida Source: Ensembl
Pore complex assembly Source: Ensembl
Positive regulation of establishment of protein localization to telomere Source: BHF-UCL
Positive regulation of protein localization to Cajal body Source: BHF-UCL
Positive regulation of telomerase RNA localization to Cajal body Source: BHF-UCL
Positive regulation of telomere maintenance via telomerase Source: BHF-UCL
Protein folding Source: FlyBase
Protein stabilization Source: BHF-UCL
Toxin transport Source: Ensembl

Cellular Location

Cytoplasm

More Infomation

References

Danni, X., Jiangzheng, Z., Huamao, S., Yinglian, P., Changcheng, Y., & Yanda, L. (2021). Chaperonin containing TCP1 subunit 3 (CCT3) promotes cisplatin resistance of lung adenocarcinoma cells through targeting the Janus kinase 2/signal transducers and activators of transcription 3 (JAK2/STAT3) pathway. Bioengineered, 12(1), 7335-7347.

Qian, T., Cui, L., Liu, Y., Cheng, Z., Quan, L., Zeng, T., ... & Si, C. (2020). High expression of chaperonin-containing TCP1 subunit 3 may induce dismal prognosis in multiple myeloma. The pharmacogenomics journal, 20(4), 563-573.

Qu, H., Zhu, F., Dong, H., Hu, X., & Han, M. (2020). Upregulation of CCT-3 induces breast cancer cell proliferation through miR-223 competition and Wnt/β-catenin signaling pathway activation. Frontiers in oncology, 10.

Hou, J. Y., Wu, H. Y., He, R. Q., Lin, P., Dang, Y. W., & Chen, G. (2019). Clinical and prognostic value of chaperonin containing T-complex 1 subunit 3 in hepatocellular carcinoma: a study based on microarray and RNA-sequencing with 4272 cases. Pathology-Research and Practice, 215(1), 177-194.

Li, L. J., Zhang, L. S., Han, Z. J., He, Z. Y., Chen, H., & Li, Y. M. (2017). Chaperonin containing TCP-1 subunit 3 is critical for gastric cancer growth. Oncotarget, 8(67), 111470.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Mouse Anti-CCT3 Recombinant Antibody (CF065) (CAT#: CBMAB-FT392LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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