Mouse Anti-COL3A1 Recombinant Antibody (CBCNC-259) (CBMAB-C2605-CN)

Name: Mouse Anti-COL3A1 Recombinant Antibody (CBCNC-259)
SKU: CBMAB-C2605-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBCNC-259

Application

ELISA, IF, IHC-P, IF

Immunogen

Acid-digested pepsin soluble human type III collagen.

Host Species

Mouse

Specificity

Human, Dog, Rat

Antibody Isotype

IgG1, κ

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
ELISA	1:800

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

15mM sodium azide

Concentration

1 mg/ml

More Infomation

Target

Full Name

Collagen Type III Alpha 1 Chain

Introduction

COL3A1 (Collagen Type III Alpha 1 Chain) is a Protein Coding gene. Diseases associated with COL3A1 include Ehlers-Danlos Syndrome, Vascular Type and Acrogeria, Gottron Type. Among its related pathways are Integrin Pathway and ERK Signaling. Gene Ontology (GO) annotations related to this gene include integrin binding and SMAD binding. An important paralog of this gene is COL2A1.

Entrez Gene ID

Human	1281
Rat	84032

UniProt ID

Human	P02461
Rat	P13941

Alternative Names

Collagen Type III Alpha 1 Chain; Ehlers-Danlos Syndrome Type IV, Autosomal Dominant; Collagen, Type III, Alpha 1; Collagen Alpha-1(III) Chain; Alpha-1 Type III Collagen; Alpha1 (III) Collagen; Collagen, Fetal; EDSVASC; EDS4A;

Function

Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12.

Biological Process

Cell-matrix adhesion Source: UniProtKB
Cerebral cortex development Source: UniProtKB
Collagen fibril organization Source: UniProtKB
Extracellular matrix organization Source: GO_Central
Heart development Source: UniProtKB
Integrin-mediated signaling pathway Source: UniProtKB
Negative regulation of immune response Source: UniProtKB
Negative regulation of neuron migration Source: UniProtKB
Peptide cross-linking Source: UniProtKB
Platelet activation Source: UniProtKB
Positive regulation of Rho protein signal transduction Source: UniProtKB
Regulation of immune response Source: Reactome
Response to cytokine Source: UniProtKB
Response to mechanical stimulus Source: Ensembl
Response to radiation Source: UniProtKB
Skeletal system development Source: Ensembl
Skin development Source: UniProtKB
Supramolecular fiber organization Source: UniProtKB
Transforming growth factor beta receptor signaling pathway Source: UniProtKB
Wound healing Source: UniProtKB

Cellular Location

Extracellular matrix

Involvement in disease

Ehlers-Danlos syndrome, vascular type (EDSVASC):
A severe form of Ehlers-Danlos syndrome, a group of connective tissue disorders characterized by skin hyperextensibility, articular hypermobility, and tissue fragility. EDSVASC is an autosomal dominant disease characterized by joint and dermal manifestations as in other forms of the syndrome, and by proneness to spontaneous rupture of bowel and large arteries. The vascular complications may affect all anatomical areas.
Polymicrogyria with or without vascular-type Ehlers-Danlos syndrome (PMGEDSV):
An autosomal recessive disorder with a highly variable phenotype and onset in early childhood. Disease features include cobblestone-like malformation of the cortex, polymicrogyria, intellectual and motor developmental delay, small joint hypermobility, vascular fragility, aneurysms, thin translucent skin and easy bruising, congenital heart defects, and foot deformities. Early death due to vascular dissection may occur.

PTM

Proline residues at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
O-linked glycan consists of a Glc-Gal disaccharide bound to the oxygen atom of a post-translationally added hydroxyl group.

Niu, K., Chen, X., & Lu, Y. (2021). COL3A1 rs1800255 polymorphism is associated with pelvic organ prolapse susceptibility in Caucasian individuals: Evidence from a meta-analysis. PloS one, 16(4), e0250943.

Mamoor, S. (2021). Differential expression of collagen type III alpha 1 chain in human epithelial ovarian cancer.

Huang, R., Li, Z., Zhu, X., Yan, P., Song, D., Yin, H., ... & Huang, Z. (2020). Collagen Type III Alpha 1 chain regulated by GATA‐Binding Protein 6 affects Type II IFN response and propanoate metabolism in the recurrence of lower grade glioma. Journal of cellular and molecular medicine, 24(18), 10803-10815.

Shi, Y., Zheng, C., Jin, Y., Bao, B., Wang, D., Hou, K., ... & Teng, Y. (2020). Reduced expression of METTL3 promotes metastasis of triple-negative breast cancer by m6A methylation-mediated COL3A1 up-regulation. Frontiers in oncology, 1126.

Teixeira, F. H., Fernandes, C. E., do Souto, R. P., & de Oliveira, E. (2020). Polymorphism rs1800255 from COL3A1 gene and the risk for pelvic organ prolapse. International urogynecology journal, 31(1), 73-78.

Kuivaniemi, H., & Tromp, G. (2019). Type III collagen (COL3A1): Gene and protein structure, tissue distribution, and associated diseases. Gene, 707, 151-171.

Ballengee, C. R., Stidham, R. W., Liu, C., Kim, M. O., Prince, J., Mondal, K., ... & Kugathasan, S. (2019). Association between plasma level of collagen type III alpha 1 chain and development of strictures in pediatric patients with Crohn’s disease. Clinical Gastroenterology and Hepatology, 17(9), 1799-1806.

Engqvist, H., Parris, T. Z., Kovács, A., Nemes, S., Werner Rönnerman, E., De Lara, S., ... & Helou, K. (2019). Immunohistochemical validation of COL3A1, GPR158 and PITHD1 as prognostic biomarkers in early-stage ovarian carcinomas. BMC cancer, 19(1), 1-12.

D'hondt, S., Guillemyn, B., Syx, D., Symoens, S., De Rycke, R., Vanhoutte, L., ... & Malfait, F. (2018). Type III collagen affects dermal and vascular collagen fibrillogenesis and tissue integrity in a mutant Col3a1 transgenic mouse model. Matrix Biology, 70, 72-83.

Shi, J., Ma, X., Gao, Y., Fan, D., Zhu, C., Mi, Y., & Xue, W. (2017). Hydroxylation of human type III collagen alpha chain by recombinant coexpression with a viral prolyl 4-hydroxylase in Escherichia coli. The Protein Journal, 36(4), 322-331.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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For research use only. Not intended for any clinical use.

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