Mouse Anti-CSP Recombinant Antibody (CBWJC-3241) (V2LY-0125-LY59)

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Basic Information

Host Animal
Mouse
Clone
CBWJC-3241
Application
ELISA, WB
Immunogen
Recombinant P. vivax CSP.
Host Species
Mouse
Specificity
Plasmodium vivax
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium Azide
Concentration
Batch dependent
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
CSP
Entrez Gene ID
UniProt ID
Function
May have an important role in presynaptic function.
Biological Process
Exocytosis Source: FlyBase
Negative regulation of response to wounding Source: FlyBase
Neuron cellular homeostasis Source: FlyBase
Protein folding Source: FlyBase
Regulation of neuromuscular synaptic transmission Source: FlyBase
Regulation of synaptic vesicle cycle Source: SynGO
Synaptic vesicle exocytosis Source: FlyBase
Cellular Location
Membrane
PTM
Fatty acylated. Heavily palmitoylated in the cysteine string motif.

Montero, K. F., Berberian, M. V., Mayorga, L. S., Tomes, C. N., & Ruete, M. C. (2022). The molecular chaperone Cysteine String Protein is required to stabilize trans-SNARE complexes during human sperm acrosomal exocytosis. bioRxiv.

Berberian, M. V., Mayorga, L. S., Tomes, C. N., & Ruete, M. C. (2022). The molecular chaperone Cysteine String Protein is required to stabilize trans-SNARE complexes during human sperm acrosomal exocytosis.

Gundersen, C. B. (2020). Cysteine string proteins. Progress in Neurobiology, 188, 101758.

Nieto-González, J. L., Gómez-Sánchez, L., Mavillard, F., Linares-Clemente, P., Rivero, M. C., Valenzuela-Villatoro, M., ... & Fernández-Chacón, R. (2019). Loss of postnatal quiescence of neural stem cells through mTOR activation upon genetic removal of cysteine string protein-α. Proceedings of the National Academy of Sciences, 116(16), 8000-8009.

Mulcahy, B., Ibbett, P., Holden-Dye, L., & O'connor, V. (2019). The Caenorhabditis elegans cysteine-string protein homologue DNJ-14 is dispensable for neuromuscular junction maintenance across ageing. Journal of Experimental Biology, 222(22), jeb205450.

Valenzuela-Villatoro, M., García-Junco-Clemente, P., Nieto-González, J. L., & Fernández-Chacón, R. (2018). Presynaptic neurodegeneration: CSP-α/DNAJC5 at the synaptic vesicle cycle and beyond. Current Opinion in Physiology, 4, 65-69.

Shirafuji, T., Ueyama, T., Adachi, N., Yoshino, K. I., Sotomaru, Y., Uwada, J., ... & Sakai, N. (2018). The role of cysteine string protein α phosphorylation at serine 10 and 34 by Protein Kinase Cγ for Presynaptic Maintenance. Journal of Neuroscience, 38(2), 278-290.

Deng, J., Koutras, C., Donnelier, J., Alshehri, M., Fotouhi, M., Girard, M., ... & Braun, J. E. (2017). Neurons export extracellular vesicles enriched in cysteine string protein and misfolded protein cargo. Scientific reports, 7(1), 1-12.

Diez-Ardanuy, C., Greaves, J., Munro, K. R., Tomkinson, N. C., & Chamberlain, L. H. (2017). A cluster of palmitoylated cysteines are essential for aggregation of cysteine-string protein mutants that cause neuronal ceroid lipofuscinosis. Scientific reports, 7(1), 1-10.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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