Rabbit Anti-CTNNA3 Recombinant Antibody (CBWJC-3354) (CBMAB-C4565WJ)

Name: Rabbit Anti-CTNNA3 Recombinant Antibody (CBWJC-3354)
SKU: CBMAB-C4565WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

CBWJC-3354

Application

ELISA, WB, IHC-P

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 700-895 of human CTNNA3.

Host Species

Rabbit

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Clonality

Monoclonal Antibody

Application Notes

Application	Note
ELISA	1 μg/mL
WB	1:500-1:1,000
IHC-P	1:50-1:200

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.3, 50% glycerol, 0.05% BSA

Preservative

0.02% sodium azide

Concentration

2 mg/ml

More Infomation

Target

Full Name

Catenin Alpha 3

Entrez Gene ID

Human	29119
Mouse	216033
Rat	361839

UniProt ID

Human	Q9UI47
Mouse	Q65CL1
Rat	A0A1S3F909

Function

May be involved in formation of stretch-resistant cell-cell adhesion complexes.

Biological Process

Actin filament organization Source: InterPro
Bundle of His cell-Purkinje myocyte adhesion involved in cell communication Source: BHF-UCL
Cell-cell adhesion Source: UniProtKB
Cell migration Source: GO_Central
Epithelial cell-cell adhesion Source: InterPro
Regulation of heart rate by cardiac conduction Source: BHF-UCL
Regulation of ventricular cardiac muscle cell action potential Source: BHF-UCL

Cellular Location

Cytoskeleton. Localizes to intercalated disks of cardiomyocytes and in peritubular myoid cells of testis, and colocalizes with CTNNA1 and CTNNA2.

Involvement in disease

Arrhythmogenic right ventricular dysplasia, familial, 13 (ARVD13):
A congenital heart disease characterized by infiltration of adipose and fibrous tissue into the right ventricle and loss of myocardial cells, resulting in ventricular and supraventricular arrhythmias.

Gehlen, J., Giel, A. S., Köllges, R., Haas, S. L., Zhang, R., Trcka, J., ... & Schumacher, J. (2022). First genome-wide association study of esophageal atresia identifies three genetic risk loci at CTNNA3, FOXF1/FOXC2/FOXL1, and HNF1B. Human Genetics and Genomics Advances, 3(2).

Pavel, M., Park, S. J., Tanasa, R., & Rubinsztein, D. C. (2021). Cell type-specific YAP1-WWTR1/TAZ transcriptional responses after autophagy perturbations are determined by levels of α-catenins (CTNNA1 and CTNNA3). Autophagy, 17(7), 1788-1790.

Shi, C. H., Cheng, Y., Tang, M. B., Liu, Y. T., Yang, Z. H., Li, F., ... & Xu, Y. M. (2018). Analysis of single nucleotide polymorphisms of STK32B, PPARGC1A and CTNNA3 gene with sporadic Parkinson's disease susceptibility in Chinese Han population. Frontiers in neurology, 9, 387.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

CTNNA3 Matched Antibody Pair (316) (CAT#: APMAB-316LY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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