Mouse Anti-CTSZ Recombinant Antibody (CBFYC-2465) (V2LY-0125-LY497)

Name: Mouse Anti-CTSZ Recombinant Antibody (CBFYC-2465)
SKU: V2LY-0125-LY497
Rating: 5 (1 reviews)

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Published Data

Mouse Anti-CTSZ Recombinant Antibody (CBFYC-2465) (V2LY-0125-LY497) in WB

Western blot analysis of cathepsin expression in esophageal cancer cell lines with KB (human cervical carcinoma) used as a positive control. ...View More

Kennedy, G. T., Azari, F. S., Nadeem, B., Chang, A., Segil, A., Bernstein, E., ... & Singhal, S. (2022). Preclinical evaluation of an activity-based probe for intraoperative imaging of esophageal cancer. Molecular Imaging, 2022, 5447290. Distributed under Open Access license CC BY 4.0, without modification.

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYC-2465

Application

WB, IP, IF, ELISA, IHC-P

Immunogen

Amino acids 277-303 at the C-terminus of human cathepsin Z.

Host Species

Mouse

Specificity

Human, Mouse, Rat, Pig

Antibody Isotype

IgG1, κ

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:100-1:1,000
IP	1-2 μg per 100-500 μg of total protein (1 mL of cell lysate)
IF(ICC)	1:50-1:500
ELISA	1:100-1:1,000
IHC-P	1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

Gelatin & PBS

Preservative

Sodium Azide

Concentration

0.2 mg/mL

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Cathepsin Z

Entrez Gene ID

1522

UniProt ID

Q9UBR2

Function

Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity (PubMed:10504234).

Capable of producing kinin potentiating peptides (By similarity).

Biological Process

Angiotensin maturation Source: Reactome
COPII vesicle coating Source: Reactome
Endoplasmic reticulum to Golgi vesicle-mediated transport Source: Reactome
Negative regulation of plasminogen activation Source: CAFA
Negative regulation of protein binding Source: CAFA
Neutrophil degranulation Source: Reactome
Proteolysis Source: CAFA
Proteolysis involved in cellular protein catabolic process Source: GO_Central
Regulation of neuron death Source: CAFA

Cellular Location

Lysosome

Batista, A. A. S., Franco, B. M., Perez, M. M., Pereira, E. G., Rodrigues, T., Wroclawski, M. L., ... & Suarez, E. R. (2021). Decreased levels of cathepsin Z mRNA expressed by immune blood cells: diagnostic and prognostic implications in prostate cancer. Brazilian Journal of Medical and Biological Research, 54.

Choi, K. M., Joo, M. S., Cho, D. H., Han, H. J., Kim, M. S., Cho, M. Y., ... & Park, C. I. (2019). Functional analysis and gene expression profiling of extracellular cathepsin Z in red sea bream, Pagrus major. Fish & Shellfish Immunology, 93, 208-215.

Lewis, M. S., Danelishvili, L., Rose, S. J., & Bermudez, L. E. (2019). MAV_4644 Interaction with the host cathepsin Z protects Mycobacterium avium subsp. hominissuis from rapid macrophage killing. Microorganisms, 7(5), 144.

Cai, X., Gao, C., Song, H., Yang, N., Fu, Q., Tan, F., & Li, C. (2019). Characterization, expression profiling and functional characterization of cathepsin Z (CTSZ) in turbot (Scophthalmus maximus L.). Fish & Shellfish Immunology, 84, 599-608.

Fang, Y., Zhang, D., Hu, T., Zhao, H., Zhao, X., Lou, Z., ... & Ye, L. C. (2019). KMT2A histone methyltransferase contributes to colorectal cancer development by promoting cathepsin Z transcriptional activation. Cancer medicine, 8(7), 3544-3552.

Aiba, Y., Harada, K., Ito, M., Suematsu, T., Aishima, S., Hitomi, Y., ... & Nakamura, M. (2018). Increased expression and altered localization of cathepsin Z are associated with progression to jaundice stage in primary biliary cholangitis. Scientific reports, 8(1), 1-11.

Li, W., Yu, X., Ma, X., Xie, L., Xia, Z., Liu, L., ... & Liu, H. (2018). Deguelin attenuates non-small cell lung cancer cell metastasis through inhibiting the CtsZ/FAK signaling pathway. Cellular Signalling, 50, 131-141.

Allan, E. R., Campden, R. I., Ewanchuk, B. W., Tailor, P., Balce, D. R., McKenna, N. T., ... & Yates, R. M. (2017). A role for cathepsin Z in neuroinflammation provides mechanistic support for an epigenetic risk factor in multiple sclerosis. Journal of Neuroinflammation, 14(1), 1-11.

Godahewa, G. I., Perera, N. C. N., Lee, S., Kim, M. J., & Lee, J. (2017). A cysteine protease (cathepsin Z) from disk abalone, Haliotis discus discus: genomic characterization and transcriptional profiling during bacterial infections. Gene, 627, 500-507.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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