Rabbit Anti-DCP1A Recombinant Antibody (EG934) (CBMAB-EN1106-LY)

Name: Rabbit Anti-DCP1A Recombinant Antibody (EG934)
SKU: CBMAB-EN1106-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

EG934

Application

FC, IF, IHC-P, WB

Immunogen

Recombinant protein within Human Dcp1a aa 460-582.

Host Species

Rabbit

Specificity

Human, Mouse

Antibody Isotype

IgG

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:500-1:2,000
IHC-P	1:50-1:200
IF(ICC)	1:50-1:200
FC	1:50-1:100

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

TBS, pH 7.4, 40% glycerol, 0.05% BSA

Preservative

0.05% sodium azide

Concentration

1 mg/ml

More Infomation

Target

Full Name

Decapping MRNA 1A

Entrez Gene ID

Human	55802
Mouse	75901

UniProt ID

Human	Q9NPI6
Mouse	Q91YD3

Function

Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1.

Biological Process

Deadenylation-dependent decapping of nuclear-transcribed mRNA Source: GO_Central
Deadenylation-independent decapping of nuclear-transcribed mRNA Source: GO_Central
Exonucleolytic catabolism of deadenylated mRNA Source: Reactome
Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
Positive regulation of catalytic activity Source: InterPro
Protein localization to cytoplasmic stress granule Source: AgBase
Regulation of mRNA stability Source: Reactome

Cellular Location

Nucleus; P-body. Co-localizes with NANOS3 in the processing bodies (By similarity). Predominantly cytoplasmic, in processing bodies (PB) (PubMed:16364915). Nuclear, after TGFB1 treatment. Translocation to the nucleus depends on interaction with SMAD4 (PubMed:11836524).

Ibayashi, M., Aizawa, R., & Tsukamoto, S. (2021). mRNA decapping factor Dcp1a is essential for embryonic growth in mice. Biochemical and Biophysical Research Communications, 555, 128-133.

Zhu, X., Chen, J., Tian, L., Zhou, Y., Xu, S., Long, S., ... & Xiao, S. (2020). Porcine deltacoronavirus nsp5 cleaves DCP1A To decrease Its antiviral activity. Journal of virology, 94(15), e02162-19.

Aeby, E., Lee, H. G., Lee, Y. W., Kriz, A., Del Rosario, B. C., Oh, H. J., ... & Lee, J. T. (2020). Decapping enzyme 1A breaks X-chromosome symmetry by controlling Tsix elongation and RNA turnover. Nature cell biology, 22(9), 1116-1129.

Wang, Y., Wang, H., Zhang, J., Chu, Z., Liu, P., Zhang, X., ... & Gu, X. (2020). Circ_0007031 serves as a sponge of miR-760 to regulate the growth and chemoradiotherapy resistance of colorectal cancer via regulating DCP1A. Cancer Management and Research, 12, 8465.

Wang, Y., Guo, W., Tang, K., Wang, Y., Zan, L., & Yang, W. (2019). Bta-miR-34b regulates milk fat biosynthesis by targeting mRNA decapping enzyme 1A (DCP1A) in cultured bovine mammary epithelial cells. Journal of animal science, 97(9), 3823-3831.

Wu, C., Liu, W., Ruan, T., Zhu, X., Tao, K., & Zhang, W. (2018). Overexpression of mRNA‑decapping enzyme 1a affects survival rate in colorectal carcinoma. Oncology Letters, 16(1), 1095-1100.

Tang, Y., Xie, C., Zhang, Y., Qin, Y., & Zhang, W. (2018). Overexpression of mRNA-decapping enzyme 1a predicts disease-specific survival in malignant melanoma. Melanoma Research, 28(1), 30-36.

Wu, C., Zhu, X., Tao, K., Liu, W., Ruan, T., Wan, W., ... & Zhang, W. (2018). MALAT1 promotes the colorectal cancer malignancy by increasing DCP1A expression and miR203 downregulation. Molecular Carcinogenesis, 57(10), 1421-1431.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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