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Rabbit Anti-DCTPP1 Recombinant Antibody (074) (V2LY-0125-LY1259)


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Summary

Host Animal
Rabbit
Specificity
Human
Clone
074
Antibody Isotype
IgG
Application
ELISA

Basic Information

Immunogen
Recombinant human XTP3TPA / DCTPP1 protein.
Host Species
Rabbit
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
ELISA1:5,000-1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
Batch dependent
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
DCTP Pyrophosphatase 1
Entrez Gene ID
79077
UniProt ID
Q9H773
Function
Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.
Biological Process
dCTP catabolic process Source: UniProtKB
DNA protection Source: UniProtKB
Nucleoside triphosphate catabolic process Source: UniProtKB
Cellular Location
Cytosol; Nucleus; Mitochondrion
More Infomation

Niu, M., Shan, M., Liu, Y., Song, Y., Han, J. G., Sun, S., ... & Zhang, G. Q. (2021). DCTPP1, an oncogene regulated by miR-378a-3p, promotes proliferation of breast cancer via DNA repair signaling pathway. Frontiers in oncology, 11, 723.

Mamoor, S. (2021). Differential expression of dCTP pyrophosphatase 1 in cancers of the breast.

Martínez-Arribas, B., Requena, C. E., Pérez-Moreno, G., Ruíz-Pérez, L. M., Vidal, A. E., & González-Pacanowska, D. (2020). DCTPP1 prevents a mutator phenotype through the modulation of dCTP, dTTP and dUTP pools. Cellular and Molecular Life Sciences, 77(8), 1645-1660.

Yue, Z., Shusheng, J., Hongtao, S., Shu, Z., Lan, H., Qingyuan, Z., ... & Yuanxi, H. (2020). Silencing DSCAM-AS1 suppresses the growth and invasion of ER-positive breast cancer cells by downregulating both DCTPP1 and QPRT. Aging (Albany NY), 12(14), 14754.

Friese, A., Kapoor, S., Schneidewind, T., Vidadala, S. R., Sardana, J., Brause, A., ... & Waldmann, H. (2019). Chemical genetics reveals a role of dCTP pyrophosphatase 1 in Wnt signaling. Angewandte Chemie, 131(37), 13143-13147.

Lu, J., Dong, W., He, H., Han, Z., Zhuo, Y., Mo, R., ... & Zhong, W. (2018). Autophagy induced by overexpression of DCTPP1 promotes tumor progression and predicts poor clinical outcome in prostate cancer. International journal of biological macromolecules, 118, 599-609.

Llona-Minguez, S., Hoglund, A., Wiita, E., Almlof, I., Mateus, A., Calderon-Montano, J. M., ... & Helleday, T. (2017). Identification of triazolothiadiazoles as potent inhibitors of the dCTP pyrophosphatase 1. Journal of Medicinal Chemistry, 60(5), 2148-2154.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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