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Mouse Anti-DCTPP1 Recombinant Antibody (X0008) (V2LY-0125-LY1257)


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Published Data
V2LY-0125-LY1257-1
Mouse Anti-DCTPP1 Recombinant Antibody (X0008) (V2LY-0125-LY1257) in IHC
DCTPP1 expression in one tissue core before (left panel) and after (right panel) QuPath analysis based on staining intensity in tumour cells. A histoscore of 115.739 was calculated based on the proportion of positive cells and their staining intensity. DCK expression in a second tissue core before (left panel) and after (right panel) QuPath analysis based on staining intensity in tumour cells. A histoscore of 69.4313 was calculated based on the proportion of positive cells and their staining intensity. ...View More
Sarr, A., Bré, J., Um, I. H., Chan, T. H., Mullen, P., Harrison, D. J., & Reynolds, P. A. (2019). Genome-scale CRISPR/Cas9 screen determines factors modulating sensitivity to ProTide NUC-1031. Scientific reports, 9(1), 7643. Distributed under Open Access license CC BY 4.0, without modification.
V2LY-0125-LY1257-2
Mouse Anti-DCTPP1 Recombinant Antibody (X0008) (V2LY-0125-LY1257) in WB
DCK and DCTPP1 protein expression analyzed by Western blot in MiaPaCa2 and A2780 cells transfected with a pX333 plasmid containing sgRNA sequences targeting DCK (sgDCK) and DCTPP1 (sgDCTPP1) or a non-targeting scrambled control sgRNA (sgScr). ...View More
Sarr, A., Bré, J., Um, I. H., Chan, T. H., Mullen, P., Harrison, D. J., & Reynolds, P. A. (2019). Genome-scale CRISPR/Cas9 screen determines factors modulating sensitivity to ProTide NUC-1031. Scientific reports, 9(1), 7643. Distributed under Open Access license CC BY 4.0, without modification.

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
X0008
Antibody Isotype
IgG2a, κ
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Amino acids 59-125 mapping within an internal region of human XTP3TPA.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:100-1:1,000
IP1-2 μg per 100-500 μg of total protein (1 mL of cell lysate)
IF(ICC)1:50-1:500
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Gelatin & PBS
Preservative
Sodium Azide
Concentration
0.2 mg/mL
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
DCTP Pyrophosphatase 1
Entrez Gene ID
79077
UniProt ID
Q9H773
Function
Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.
Biological Process
dCTP catabolic process Source: UniProtKB
DNA protection Source: UniProtKB
Nucleoside triphosphate catabolic process Source: UniProtKB
Cellular Location
Cytosol; Nucleus; Mitochondrion
More Infomation

Niu, M., Shan, M., Liu, Y., Song, Y., Han, J. G., Sun, S., ... & Zhang, G. Q. (2021). DCTPP1, an oncogene regulated by miR-378a-3p, promotes proliferation of breast cancer via DNA repair signaling pathway. Frontiers in oncology, 11, 723.

Mamoor, S. (2021). Differential expression of dCTP pyrophosphatase 1 in cancers of the breast.

Martínez-Arribas, B., Requena, C. E., Pérez-Moreno, G., Ruíz-Pérez, L. M., Vidal, A. E., & González-Pacanowska, D. (2020). DCTPP1 prevents a mutator phenotype through the modulation of dCTP, dTTP and dUTP pools. Cellular and Molecular Life Sciences, 77(8), 1645-1660.

Yue, Z., Shusheng, J., Hongtao, S., Shu, Z., Lan, H., Qingyuan, Z., ... & Yuanxi, H. (2020). Silencing DSCAM-AS1 suppresses the growth and invasion of ER-positive breast cancer cells by downregulating both DCTPP1 and QPRT. Aging (Albany NY), 12(14), 14754.

Friese, A., Kapoor, S., Schneidewind, T., Vidadala, S. R., Sardana, J., Brause, A., ... & Waldmann, H. (2019). Chemical genetics reveals a role of dCTP pyrophosphatase 1 in Wnt signaling. Angewandte Chemie, 131(37), 13143-13147.

Lu, J., Dong, W., He, H., Han, Z., Zhuo, Y., Mo, R., ... & Zhong, W. (2018). Autophagy induced by overexpression of DCTPP1 promotes tumor progression and predicts poor clinical outcome in prostate cancer. International journal of biological macromolecules, 118, 599-609.

Llona-Minguez, S., Hoglund, A., Wiita, E., Almlof, I., Mateus, A., Calderon-Montano, J. M., ... & Helleday, T. (2017). Identification of triazolothiadiazoles as potent inhibitors of the dCTP pyrophosphatase 1. Journal of Medicinal Chemistry, 60(5), 2148-2154.

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For research use only. Not intended for any clinical use.

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